| 摘要: |
| 目的：基于数据挖掘探讨中医药治疗绝经后骨质疏松症脾肾亏虚证的用药规律。方法：检索中国知网（China National Knowledge Infrastructure，CNKI）、万方数据（WANFANG DATA）、维普中文科技期刊数据库（VIP Information，VIP）自建库至2026年2月15日关于中医药治疗绝经后骨质疏松症脾肾亏虚证的文献，筛选符合标准的文献及处方，进行药物使用频次、功效、性味归经、关联规则及聚类分析。结果：共筛选出有效文献53篇，纳入处方53首，涉及中药105味，高频中药使用频次前10位者依次为淫羊藿、黄芪、熟地黄、骨碎补、当归、杜仲、白术、补骨脂、丹参、茯苓；药物功效以补虚药为主，活血化瘀药为辅；四气以温为主，五味以甘、辛为主；归经以肝、肾、脾经为主。关联规则分析得到12种药物组合，支持度最高的对药为淫羊藿-丹参，支持度最高的角药为熟地黄-当归-黄芪。聚类分析得出3个新方组合。结论：中药治疗绝经后骨质疏松症脾肾亏虚证以补虚药为主、活血化瘀药为辅，遵循脾肾同治、肌骨并重的治疗原则，可为临床诊治提供一定参考。 |
| 关键词: 绝经后骨质疏松症 脾肾亏虚型 数据挖掘 用药规律 |
| DOI： |
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| Medication rule of traditional Chinese medicine in treatment of postmenopausal osteoporosis with spleen-kidney deficiency: A study based on data mining |
| WANG Pengwen,LIU Xiaolan |
| (The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410006, Hunan, China) |
| Abstract: |
| Objective: To investigate the medication rule of traditional Chinese medicine （TCM） in the treatment of postmenopausal osteoporosis with spleen-kidney deficiency based on data mining. Methods: CNKI, WANFANG DATA, and VIP were searched for articles on TCM treatment of postmenopausal osteoporosis with spleen-kidney deficiency published up to February 15, 2026. The articles and prescriptions meeting the inclusion criteria were screened, and the drugs were analyzed in terms of frequency of use, function, nature/taste/meridian entry, association rule, and cluster analysis. Results: A total of 53 valid articles were obtained, with 53 prescriptions involving 105 TCM drugs. The top 10 drugs in terms of frequency of use were Herba Epimedii, Astragalus membranaceus, prepared Radix Rehmanniae, Rhizoma Drynariae, Angelica sinensis, Eucommia ulmoides, Atractylodes macrocephala Koidz., Fructus Psoraleae, Salvia miltiorrhiza, and Poria cocos. Most drugs were deficiency-tonifying herbs, assisted by blood-activating and stasis-resolving drugs. Most drugs had a warm nature and a sweet or pungent taste, and they mainly entered the liver, kidney, and spleen meridians. The association rule analysis identified 12 drug combinations, among which Herba Epimedii-Salvia miltiorrhiza was the drug pair with the highest degree of support and prepared Radix Rehmanniae-Angelica sinensis-Astragalus membranaceus was the drug triplet with the highest degree of support. The cluster analysis obtained three new prescriptions. Conclusion: Deficiency-tonifying herbs are mainly used for the treatment of postmenopausal osteoporosis with spleen-kidney deficiency, with the assistance of blood-activating and stasis-resolving drugs. The treatment follows the principles of treating the spleen and the kidney simultaneously and placing equal emphasis on muscles and bones, which provides a certain reference for clinical diagnosis and treatment. |
| Key words: postmenopausal osteoporosis spleen-kidney deficiency data mining medication rule |
