| 摘要: |
| 目的：观察腕踝针疗法联合托烷司琼对肺癌顺铂化疗相关性恶心呕吐（chemotherapy-induced nausea and vomiting,CINV）控制率、血清5-羟色胺（5-hydroxytryptamine，5-HT）水平及生活质量的影响。方法：将肺癌顺铂化疗患者60例随机分为观察组与对照组，每组各30例。对照组予以托烷司琼静脉滴注干预，观察组在对照组基础上联合腕踝针疗法干预，2组均连续干预4 d。比较2组干预后第1～4天（D1～D4）每天的CINV控制率、干预前后血清5-HT浓度变化及卡氏功能状态评分（Karnofsky Performance Status，KPS）改善情况和不良反应发生情况。结果：干预后D3、D4观察组CINV控制率分别为57.14%（16/28）、64.29%（18/28），高于对照组的32.14%（9/28）、35.17%（10/28），差异均有统计学意义（P<0.05）；2组血清5-HT水平、KPS评分干预前后组内比较及干预后组间比较，差异均有统计学意义（P<0.05）；2组干预期间均未出现严重不良反应。结论：腕踝针联合托烷司琼能更有效地抑制顺铂化疗延迟期血清5-HT的释放，提高CINV控制率，改善患者生活质量，且安全性良好，为中西医结合防治CINV提供了临床证据。 |
| 关键词: 化疗相关性恶心呕吐 肺癌化疗 中西医结合疗法 托烷司琼 腕踝针 随机对照试验 |
| DOI： |
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| Clinical effect of wrist-ankle acupuncture in treatment of chemotherapy-induced nausea and vomiting: An analysis of 28 cases |
| ZENG Yiming,WANG Zhu,WU Qinjing,FENG Lan,HE Fengjiao,ZHU Wei,LI Rong |
| (Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Changsha 410006, Hunan, China) |
| Abstract: |
| Objective: To investigate the effect of wrist-ankle acupuncture combined with tropisetron on the control rate of chemotherapy-induced nausea and vomiting （CINV）, the level of 5-hydroxytryptamine （5-HT）in serum, and quality of life in patients with lung cancer undergoing cisplatin chemotherapy. Methods: A total of 60 patients with lung cancer who underwent cisplatin chemotherapy were randomly divided into observation group and control group, with 30 patients in each group. The patients in the control group were given intravenous drip of tropisetron, while those in the observation group were given wrist-ankle acupuncture in addition to the treatment in the control group, and the course of treatment was 4 consecutive days for both groups. The two groups were compared in terms of CINV control rate on days 1-4 （D1-D4） after intervention, the change in the serum concentration of 5-HT after intervention, and the improvement in Karnofsky Performance Status （KPS） score after intervention ,and adverse reactions. Results: Compared with the control group, the observation group had a significantly higher CINV control rate on D3 ［57.14% （16/28） vs. 32.14% （9/28）, P < 0.05］ and D4 ［64.29% （18/28） vs. 35.71% （10/28）, P < 0.05］. After treatment, both groups had significant changes in the serum level of 5-HT and KPS score, and there were significant differences in these two indicators between the two groups after treatment （P < 0.05）. No serious adverse event was observed in either group during intervention. Conclusion: Wrist-ankle acupuncture combined with tropisetron can more effectively inhibit the release of serum 5-HT in the delayed stage of cisplatin chemotherapy, improve the control rate of CINV, and enhance the quality of life of patients, with a favorable safety profile, which provides clinical evidence for the prevention and treatment of CINV by integrated traditional Chinese and Western medicine therapy. |
| Key words: chemotherapy-induced nausea and vomiting chemotherapy for lung cancer integrated traditional Chinese and Western medicine therapy tropisetron wrist-ankle acupuncture randomized controlled trial nursing |
