| 摘要: |
| 目的：基于数据挖掘技术分析袁长津教授治疗肺结节的临床用药规律。方法：收集2023年9月1日至2024年12月31日袁长津教授在湖南中医药大学第二附属医院诊治肺结节患者的门诊病历处方98首。采用数据挖掘技术中的频数统计、关联规则分析、聚类分析等方法，结合Excel 2021、Apriori算法、R语言等工具，系统分析袁教授治疗肺结节的用药规律。结果：98份中药处方涉及106味药物，使用频次≥16次的中药有22味，包括甘草、黄芩、蒲公英、柴胡、浙贝母等。药物四气以微寒、寒、平、温为主，药味以甘、苦为主，辛味次之，归经多为肺、脾、肝经，功效以补虚、清热、化痰止咳平喘为主。在置信度均为100%的3阶关联规则中，支持度最高的药对组合为“黄芩-百部-丹参”。结论：袁教授认为肺结节以肺脾气虚为本，痰瘀盘踞为标，其重用补虚药，善用甘草平补脾肺之虚，同时重视化热之机，喜用黄芩清热解郁且不易伤正，同时辅以化痰止咳平喘及活血化瘀之品，力求达到养阴不敛邪、祛瘀不伤正、散结不耗津的效果，以遏制结节生长与恶变。 |
| 关键词: 肺结节 肺脾气虚 数据挖掘 用药规律 袁长津 |
| DOI： |
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| Medication rule of Yuan Changjin in treatment of pulmonary nodules：A study based on data mining |
| PU Wanxi,PENG Sujuan |
| (The Second Affiliated Hospital of Hunan University of Chinese Medicine，Changsha 410005，Hunan，China) |
| Abstract: |
| Objective：To investigate the clinical medication rule of Yuan Changjin in the treatment of pulmonary nodules based on data mining.Methods：A total of 98 prescriptions were collected from the patients with pulmonary nodules who were treated by Professor Yuan Changjin in The Second Affiliated Hospital of Hunan University of Chinese Medicine from September 1，2023 to December 31，2024.Data mining techniques including frequency statistics，association rule analysis，and cluster analysis were used to systematically analyze the medication of Yuan Changjin in the treatment of pulmonary nodules，with the application of Excel 2021，Apriori algorithm，and R language.Results：The 98 prescriptions involved 106 traditional Chinese medicine drugs，among which there were 22 drugs with a frequency of use of ≥16，including Radix Glycyrrhizae，Scutellaria baicalensis，dandelion，Bupleurum chinense，and Fritillaria thunbergⅡ.Most drugs had a slightly cold，cold，neutral or warm nature and a sweet，bitter or pungent taste，and they mainly entered the lung，spleen，and liver meridians.The main functions of these drugs included tonifying deficiency，clearing heat，resolving phlegm，relieving cough，and alleviating asthma.Among the grade 3 association rules with a degree of confidence of 100%，Scutellaria baicalensis-Radix Stemonae-Salvia miltiorrhiza was the drug combination with the highest degree of support.Conclusion：Professor Yuan thinks that Qi deficiency of lung and spleen is the root cause of pulmonary nodules and phlegm stasis is the manifestation of pulmonary nodules.He emphasizes the use of deficiency-tonifying herbs and uses Radix Glycyrrhizae to tonify spleen and lung deficiency.In addition，he pays close attention to the timing of heat transformation and prefers Scutellaria baicalensis for clearing heat and resolving stagnation，without impairing vital Qi.He also uses phlegm-resolving，cough-relieving，asthma-relieving，blood-activating，and stasis-resolving herbs to achieve the goal of nourishing Yin without retaining pathogens，removing blood stasis without damaging vital Qi，and resolving static blood without consuming body fluids，thereby inhibiting the growth and malignant transformation of nodules. |
| Key words: pulmonary nodules Qi deficiency of lung and spleen data mining medication rule Yuan Changjin |
