| 摘要: |
| 目的：借助中医传承辅助平台（V2.5），基于现代文献探究中医药治疗阴虚型缺血性中风的用药规律。方法：搜集整理中医药治疗阴虚型缺血性中风的临床研究类文献，统计分析文献中处方各味中药的性味归经、应用频次、药对组合、药物间关联规则，演化得到核心组合及新处方。结果：共纳入符合要求的文献53篇，得到治疗阴虚型缺血性中风的方剂40首，共涉及中药110味;用药频次排名前10位的中药依次为生地黄、白芍、牛膝、当归、水蛭、丹参、钩藤、地龙、川芎、麦冬;寒性药物（157次，36.5%）、甘味药物（263次，38.2%）使用最多，药物多归肝经（310次，29.3%）。高频中药关联规则分析得出常用药对23组，包含中药14味，以“生地黄，白芍”和“牛膝，白芍”频次最高;高频中药聚类分析得到药对组合共21组，演化出6个药物核心组合，进一步分析得出3个新方组合。结论：利用中医传承辅助平台分析得出的结果，符合从肝论治阴虚型缺血性中风的临床治疗思路，即“滋肝阴、平肝阳、息肝风”。 |
| 关键词: 缺血性中风 阴虚型 用药规律 中医传承辅助平台 |
| DOI： |
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| Medication rule of traditional Chinese medicine in treatment of ischemic stroke with Yin deficiency: A study based on data mining |
| MAO Guo |
| (Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine，Changsha 410006，Hunan，China) |
| Abstract: |
| Objective：To investigate the medication rule of traditional Chinese medicine (TCM) in the treatment of ischemic stroke with Yin deficiency in modern literature using Traditional Chinese Medicine Inheritance Support System (V2.5).Methods: Clinical studies on TCM treatment of ischemic stroke with Yin deficiency were obtained，and each TCM drug in the prescriptions was analyzed in terms of nature/taste/meridian entry，frequency of use，drug combinations，and association rules，and then core combinations and new prescriptions were obtained.Results: A total of 53 articles meeting related requirements were obtained，as well as 40 prescriptions for the treatment of ischemic stroke with Yin deficiency，involving 110 TCM drugs in total.The top 10 drugs in terms of frequency of use were Radix Rehmanniae，Radix Paeoniae Alba，Radix Achyranthis Bidentatae，Angelica sinensis，leech，Salvia miltiorrhiza，Uncaria rhynchophylla，Pheretima，Rhizoma Chuanxiong，and Radix Ophiopogonis.Drugs of cold nature (157 times，36.5%) and drugs with a sweet taste (263 times，38.2%) showed the highest number of use，and the drugs mainly entered the liver meridian (310 times，29.3%).The association rule analysis of high-frequency TCM drugs obtained 23 commonly used drug combinations，including 14 TCM drugs，among which Radix Rehmanniae-Radix Paeoniae Alba and Radix Achyranthis Bidentatae-Radix Paeoniae Alba had the highest frequency.The cluster analysis of high-frequency TCM drugs obtained 21 drug combinations，which were evolved into 6 core drug combinations，and further analysis obtained 3 new prescriptions.Conclusion: The results of analysis using Traditional Chinese Medicine Inheritance Support System are consistent with the ideas of the clinical treatment of ischemic stroke with Yin deficiency from the aspect of the liver，i.e.，nourishing liver Yin，pacifying liver YANG，and extinguishing liver wind. |
| Key words: ischemic stroke Yin deficiency medication rule Traditional Chinese Medicine Inheritance Support System |
