| 摘要: |
| 目的：分析李东垣所创的消阴火方用药规律，梳理阴火证分型，为治疗内伤脾胃相关疾病提供理论依据。方法：收集《脾胃论》《兰室秘藏》《医学发明》《内外伤辨惑论》《活法机要》《东垣试效方》中的消阴火方，采用SPSS Statistics 27.0 软件对方药进行描述性统计分析、高频药物聚类分析，运用SPSS Modeler 18.0 软件进行高频药物关联规则分析。结果：共纳入消阴火方90首，涉及中药111味，药物使用频次1 058次，核心药物为当归、升麻、柴胡、炙甘草、人参、黄芪、陈皮;中药类型分为39种;其中药性以温、寒、平为主，药味以辛、苦、甘居多，归经多集中于脾、胃、肺;药物功效以行气药、辛温发散药、补气药、温里药为主;高频药物关联分析挖掘出5组常用药对和12组常用药组;高频药物聚类分析获得6组常用核心组方。阴火证核心证型有湿滞阴火证、气郁阴火证、阴虚阴火证。结论：脾胃气虚为阴火之首要病机，李东垣治疗阴火以甘温补脾为第一要务，核心方剂有补脾胃泻阴火之升阳汤、补中益气汤、益胃汤、升阳除湿汤。 |
| 关键词: 脾胃学说 阴火证 消阴火方 用药规律 数据挖掘 李东垣 |
| DOI： |
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| Medication rule of Yin-fire elimination prescriptions formulated by Li Dongyuan:A study based on data mining |
| CAO Yiming,HUANG He |
| (Hubei University of Chinese Medicine，Wuhan 430060，Hubei，China;Hubei Provincial Hospital of Traditional Chinese Medicine，Wuhan 430074，Hubei，China) |
| Abstract: |
| Objective：To investigate the medication rule of Yin-fire elimination prescriptions formulated by Li Dongyuan，to summarize the typing of Yin-fire syndrome，and to provide a theoretical basis for the treatment of diseases associated with internal injury of the spleen and stomach.Methods: Yin-fire elimination prescriptions were collected from Treatise on the Spleen and Stomach，Secret Book of Orchid Chamber，Medical Inventions，Treatise on the Differentiation of Internal and External Injuries，Essentials of Revival Methods，and Tested Prescriptions by Master Dongyuan.SPSS Statistics 27.0 was used to perform the descriptive statistical analysis of drugs in prescriptions and the cluster analysis of high-frequency drugs，and SPSS Modeler 18.0 was used to perform the association rule analysis of high-frequency drugs.Results: A total of 90 Yin-fire elimination prescriptions were obtained，involving 111 traditional Chinese medicine (TCM) drugs，with a frequency of use of 1 058 times，and the core drugs were Angelica sinensis，Rhizoma Cimicifugae，Bupleurum chinense，Radix Glycyrrhizae Preparata，Panax ginseng，Astragalus membranaceus，and tangerine peel.The TCM drugs were classified into 39 types，and most drugs had a warm，cold or neutral nature and a pungent，bitter or sweet taste，mainly entering the spleen，stomach，and lung meridians.The main types of drugs were Qi-moving drugs，pungent and warm-natured dispersing drugs，Qi-tonifying drugs，and interior-warming drugs.The association rule analysis of high-frequency drugs obtained 5 commonly used drug pairs and 12 commonly used drug combinations.The cluster analysis of high-frequency drugs obtained 6 commonly used core prescriptions.The core syndrome types of Yin-fire syndrome included dampness stagnation Yin-fire syndrome，Qi depression Yin-fire syndrome，and Yin deficiency Yin-fire syndrome.Conclusion: Deficiency of spleen Qi and stomach Qi is the primary pathogenesis of Yin-fire，and Li Dongyuan applies sweet and warm-natured spleen-tonifying drugs as the most important method in the treatment of Yin-fire.Core prescriptions include Shengyang decoction，Buzhong Yiqi decoction，Yiwei decoction，and Shengyang Chushi decoction，and these prescriptions can be used to tonify the spleen and the stomach and purge Yin-fire. |
| Key words: theory of spleen and stomach Yin-fire syndrome Yin-fire elimination prescriptions medication rule data mining Li Dongyuan |
