| 摘要: |
| 目的：探讨腹针联合黄连汤治疗2型糖尿病胃轻瘫（diabetic gastroparesis in type 2 diabetes mellitus,DGP）的临床疗效。方法：选取86 例DGP患者为研究对象，以随机数字表法将其分为治疗组和对照组，每组各43 例。2组患者均接受基础治疗，对照组予以西医治疗（口服枸橼酸莫沙必利片），治疗组在对照组的基础上给予腹针联合黄连汤治疗，2组均治疗4周。比较2组治疗后的临床疗效，治疗前后的症状积分、血糖指标、胃肠功能指标及治疗期间的不良反应。结果：总有效率治疗组为97.67%（42/43），高于对照组的83.72%（36/43），2组比较，差异有统计学意义（P＜0.05）。与治疗前比较，2组治疗后恶心呕吐、食后腹胀、嗳气、饮食减少评分降低，糖化血红蛋白（glycated hemoglobin，HbA1c）、餐后2 h血糖（2 hour postprandial blood glucose，2hPG）、空腹血糖（fasting blood glucose,FBG）水平及胃容量降低，胃排空时间缩短，胃排空率、胃窦收缩频率、胃窦收缩幅度及血清胃泌素（gastrin，GAS）水平升高，且治疗组改善优于对照组，差异均有统计学意义（P＜0.05或P＜0.01）。不良反应总发生率治疗组为13.95%（6/43），对照组为9.30%（4/43），2组比较，差异无统计学意义（P＞0.05）。结论：腹针联合黄连汤治疗DGP可改善患者血糖水平及胃肠功能，进而促进患者症状改善，提高疗效，且具有良好的安全性。 |
| 关键词: 2型糖尿病 胃轻瘫 腹针 黄连汤 血糖 胃肠功能 |
| DOI： |
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| Clinical effect of abdominal acupuncture combined with Coptis chinensis decoction in treatment of gastroparesis in type 2 diabetes mellitus: An analysis of 43 cases |
| CHENG Xuelian,LIN Chunli,WANG Yan |
| (Changhai Community Health Service Center of Yangpu District，Shanghai 200433，China) |
| Abstract: |
| Objective: To investigate the clinical effect of abdominal acupuncture combined with Coptis chinensis decoction in the treatment of diabetic gastroparesis in type 2 diabetes mellitus(DGP） .Methods: A total of 86 patients with DGP were enrolled as subjects and were divided into treatment group and control group using a random number table，with 43 patients in each group.The patients in the control group were given basic treatment and Western medicine treatment (oral administration of mosapride citrate tablets），while those in the treatment group were given abdominal acupuncture combined with Coptis chinensis decoction in addition to the treatment in the control group;the course of treatment was 4 weeks for both groups.The two groups were compared in terms of clinical outcome，symptom score，blood glucose levels，gastrointestinal function parameters，and adverse reactions.Results: The treatment group had a significantly higher overall response rate than the control group ［97.67% (42/43） vs 83.72% (36/43），P＜0.05］.After treatment，both groups had significant reductions in the scores of nausea and vomiting，abdominal distension after eating，belching，and reduction in diet，significant reductions in the levels of glycated hemoglobin (HbAlc）,2 hour postprandial blood glucose (2hPG） and fasting blood glucose (FBG），significant reductions in gastric capacity and gastric emptying time，and significant increases in gastric emptying rate，antral contraction frequency，antral contraction amplitude，and serum gastrin (GAS） ，and the treatment group had significantly better improvements than the control group (P＜0.05，P＜0.01）.There was no significant difference in the overall incidence rate of adverse reactions between the treatment group and the control group ［13.95% (6/43） vs 9.30% (4/43），P＞0.05］.Conclusion: In the treatment of DGP，abdominal acupuncture combined with Coptis chinensis decoction can improve blood glucose level and gastrointestinal function，thereby promoting the improvement in symptoms and enhancing treatment outcome，with a favorable safety profile. |
| Key words: type 2 diabetes mellitus gastroparesis abdominal acupuncture Coptis chinensis decoction blood glucose gastrointestinal function |
