| 摘要: |
| 目的：探究我院自制中成药咳喘固本丸联合布地奈德福莫特罗粉吸入剂（Ⅱ）治疗慢性阻塞性肺疾病急性加重期（acute exacerbation of chronic obstructive pulmonary disease，AECOPD）肺肾气虚证的临床疗效。方法：选择AECOPD肺肾气虚证患者96 例，采取随机数字表法将其随机分为治疗组和对照组，每组各48 例。对照组采用布地奈德福莫特罗粉吸入剂（Ⅱ）及常规治疗，治疗组在此基础上加入咳喘固本丸治疗，2组疗程均为30 d。比较2组中医证候改善情况、临床症状改善时间及治疗前后肺功能指标［第1秒用力呼气容积(forced expiratory volume in the first second，FEV1）、用力肺活量(forced vital capacity,FVC）、第1秒率（FEV1/FVC）］、血气分析指标［氧分压(partial pressure of oxygen，PaO2）、二氧化碳分压(partial pressure of carbon dioxide，PaCO2）］、慢性阻塞性肺疾病评估测试问卷（chronic obstructive pulmonary disease assessment test score，CAT）评分、改良英国版医学研究委员会呼吸困难量表（modified British Medical Research Council，mMRC）评分、改良巴塞尔指数（modified Barthel index，MBI）评分，根据中医证候及肺功能指标评定综合疗效。结果：最终有89 例患者成功完成临床研究，其中治疗组44 例，对照组45 例。总有效率治疗组为90.91%（40/44），对照组为68.89%（31/45），2组比较，差异有统计学意义（P＜0.05）。临床症状改善时间、肺功能指标（包括FEV1、FVC和FEV1/FVC）及血气分析指标（PaO2、PaCO2）、CAT评分、mMRC评分、MBI评分治疗组均优于对照组(P＜0.05）。结论：咳喘固本丸联合布地奈德福莫特罗粉吸入剂（Ⅱ）能有效改善AECOPD肺肾气虚证患者的临床症状、肺功能及日常生活能力，其疗效优于单一使用布地奈德福莫特罗粉吸入剂（Ⅱ）治疗。 |
| 关键词: 慢性阻塞性肺疾病急性加重期 肺肾气虚证 咳喘固本丸 布地奈德福莫特罗吸入粉吸入剂（Ⅱ） |
| DOI： |
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| Clinical effect of Kechuan Guben pills combined with budesonide/formoterol powder for inhalation (Ⅱ） in treatment of acute exacerbation of chronic obstructive pulmonary disease with lung-kidney Qi deficiency: An analysis of 44 cases |
| WEI Zhiqian,YANG Huihong |
| (Yueyang Municipal Hospital of Traditional Chinese Medicine，Yueyang 41400，Hunan，China) |
| Abstract: |
| Objective: To investigate the clinical effect of the self-made Chinese patent drug Kechuan Guben pills combined with budesonide/formoterol powder for inhalation (Ⅱ） in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD） with lung-kidney Qi deficiency.Methods: A total of 96 AECOPD patients with lung-kidney Qi deficiency were enrolled and divided into treatment group and control group using a random number table，with 48 patients in each group.The patients in the control group were given budesonide/formoterol powder for inhalation (Ⅱ） and conventional treatment，while those in the treatment group were given Kechuan Guben pills in addition to the treatment in the control group;the course of treatment was 30 days for both groups.The two groups were compared in terms of the improvement in traditional Chinese medicine (TCM） syndrome，time to relief of symptoms，pulmonary function parameters ［forced expiratory volume in the first second （FEV1），forced vital capacity （FVC），and FEV1/FVC ratio］，blood gas parameters ［partial pressure of oxygen （PaO2） and partial pressure of carbon dioxide （PaCO2）］，COPD assessment test score (CAT），modified British Medical Research Council Dyspnea Scale (mMRC） ，and modified Barthel index (MBI） score，and overall response was assessed based on TCM syndrome and pulmonary function parameters.Results: Finally 89 patients successfully completed the clinical study，with 44 patients in the treatment group and 45 patients in the control group.There was a significant difference in overall response rate between the treatment group and the control group ［90.91% (40/44）vs 68.89% (31/45），P＜0.05］.Compared with the control group，the treatment group had significantly better time to relief of symptoms，pulmonary function parameters (FEV1，FVC，and FEV1/FVC ratio），blood gas parameters (PaO2 and PaCO2），CAT score，mMRC score，and MBI score (P＜0.05）.Conclusion: Kechuan Guben pills combined with budesonide/formoterol powder for inhalation (Ⅱ） can effectively improve clinical symptoms，pulmonary function，and activities of daily living in AECOPD patients with lung-kidney Qi deficiency，with a better clinical effect than budesonide/formoterol powder for inhalation (Ⅱ） used alone. |
| Key words: acute exacerbation of chronic obstructive pulmonary disease lung-kidney Qi deficiency Kechuan Guben pills budesonide/formoterol powder for inhalation (Ⅱ） |
