| 摘要: |
| 目的：观察复方皂角刺汤联合顺铂腹腔灌注治疗脾虚湿阻型恶性腹水的治疗效果及安全性。方法：选取脾虚湿阻型恶性腹水患者42 例，随机分为治疗组和对照组，每组各21 例。对照组予单药顺铂腹腔灌注化疗，治疗组在对照组基础上加用复方皂角刺汤内服，比较2组治疗前后中医证候积分、腹水最大深度、卡氏功能状态评分（karnofsky performance status score，KPS评分）的变化及不良反应发生情况，评价中医证候疗效、恶性腹水缓解疗效。结果：中医证候疗效总有效率治疗组为80.95%（17/21），对照组为66.67%（14/21），恶性腹水缓解疗效总有效率治疗组为76.19%（16/21），对照组为57.14%（12/21），2组差异均有统计学意义（P＜0.05）；治疗后2组中医证候积分、腹水最大深度、KPS评分均较治疗前改善，且治疗组改善优于对照组，差异均有统计学意义（P＜0.05）；2组不良反应（恶心呕吐、腹泻、骨髓抑制）发生情况比较，差异无统计学意义（P＞0.05）。结论：复方皂角刺汤联合顺铂腹腔灌注治疗能有效消减恶性腹水，控制病情进展，提高患者生存质量。 |
| 关键词: 恶性腹水 脾虚湿阻型 复方皂角刺汤 顺铂 化疗 |
| DOI： |
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| Clinical efficacy of compound Gleditsiae Spina decoction combined with peritoneal perfusion with cisplatin in treatment of malignant ascites with spleen deficiency and dampness stagnation |
| SHI Hongli,LI Hui,LIU Shuanghao |
| (Changde Hospital Affiliated to Hunan University of Chinese Medicine，Changde 415000，Hunan，China;Changde First Hospital of Traditional Chinese Medicine，Changde 415000，Hunan，China) |
| Abstract: |
| Objective：To investigate the clinical efficacy and safety of compound Gleditsiae Spina decoction combined with peritoneal perfusion with cisplatin in the treatment of malignant ascites with spleen deficiency and dampness stagnation.Methods：A total of 42 patients with malignant ascites with spleen deficiency and dampness stagnation were enrolled and randomly divided into treatment group and control group，with 21 patients in each group.The patients in the control group received peritoneal perfusion chemotherapy with cisplatin alone，and those in the treatment group received oral administration of compound Gleditsiae Spina decoction in addition to the treatment in the control group.The two groups were compared in terms of traditional Chinese medicine （TCM）syndrome score，the maximum depth of ascites，Karnofsky Performance Scale （KPS）score，and adverse events before and after treatment，and the treatment outcomes of TCM syndrome and malignant ascites were assessed.Results：There were significant differences between the treatment group and the control group in the overall response rates of TCM syndrome［80.95% （17/21）vs 66.67% （14/21），P＜0.05］ and malignant ascites ［76.19% （16/21）vs 57.14% （12/21），P＜0.05］.After treatment，both groups had improvements in TCM syndrome score，the maximum depth of ascites，and KPS score，and the treatment group had significantly better improvements than the control group （P＜0.05）.There were no significant differences in adverse events （nausea and vomiting，diarrhea，bone marrow suppression）between the two groups （P>0.05）.Conclusion：Compound Gleditsiae Spina decoction combined with peritoneal perfusion with cisplatin can effectively alleviate malignant ascites，control disease progression，and improve the quality of life of patients. |
| Key words: malignant ascites spleen deficiency and dampness stagnation compound Gleditsiae Spina decoction cisplatin chemotherapy |
