| 摘要: |
| 目的：观察基于“命门元气三焦”学说的温针灸对卵巢储备功能减退（DOR）不孕患者卵巢功能及体外受精-胚胎移植（IVF-ET）的影响。方法：将60 例拟行鲜胚移植的DOR不孕患者随机分为治疗组和对照组，每组各30 例。治疗组于促排卵周期前1个月经周期第3天（第一阶段）实施温针灸治疗，并于促排卵周期月经期第2天（第二阶段）采用温针灸联合IVF-ET微刺激方案治疗，对照组仅于促排卵周期予以IVF-ET微刺激方案治疗。观察2组第一阶段与第二阶段（月经周期第2～3天）的血清促卵泡激素（FSH）、抗米勒管激素（AMH）、窦卵泡计数（AFC）变化及治疗后2组获卵数、优质胚胎数，并统计临床妊娠率。结果：临床妊娠率治疗组为46.67%（14/30），对照组为33.33%（10/30），差异无统计学意义（P>0.05）。治疗第二阶段时，治疗组血清FSH较治疗第一阶段降低，AFC个数较治疗第一阶段增加，且治疗组血清FSH值降低幅度及AFC增加个数均大于对照组，差异有统计学意义（均P<0.05）;治疗后治疗组获卵数及优质胚胎数均大于对照组（P<0.05）;治疗组AMH值较治疗前升高，但差异无统计学意义（P>0.05）。结论：基于“命门元气三焦”学说的温针灸治疗能改善DOR不孕患者血清性激素水平，改善卵巢功能及IVF-ET的妊娠结局。 |
| 关键词: 卵巢储备功能减退 “命门元气三焦”学说 温针灸 激素水平 卵巢功能 体外受精-胚胎移植 |
| DOI： |
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| Effect of warming acupuncture-moxibustion based on the theory of “vital gate，vital energy，and triple energizers” on in vitro fertilization-embryo transfer in patients with infertility due to diminished ovarian reserve |
| MA Li,ZHANG Meng,TANG Huizhen |
| (The Second Affiliated Hospital of Hunan University of Chinese Medicine，Changsha 410005，Hunan，China;Hunan Provincial Maternal and Child Health Care Hospital，Changsha 410005，Hunan，China) |
| Abstract: |
| Objective：To investigate the effect of warming acupuncture-moxibustion based on the theory of “vital gate，vital energy，and triple energizers” on ovarian function and in vitro fertilization-embryo transfer (IVF-ET) in patients with infertility due to diminished ovarian reserve (DOR).Methods：A total of 60 patients with infertility due to DOR who were scheduled for fresh embryo transfer were randomly divided into treatment group and control group，with 30 patients in each group.The patients in the treatment group were given warming acupuncture-moxibustion on day 3 of the menstrual cycle before ovulation induction (stage 1)，followed by warming acupuncture-moxibustion combined with IVF-ET microstimulation on day 2 of the menstrual cycle of ovulation induction (stage 2)，and those in the control group were given IVF-ET microstimulation alone in the ovulation induction cycle.The two groups were observed in terms of the changes in the serum levels of follicle-stimulating hormone (FSH)，anti-mullerian hormone (AMH)，and antral follicle count (AFC) in stage 1 and stage 2 (on days 2-3 of menstrual cycle)，as well as the number of retrieved oocytes and the number of high-quality embryos after treatment，and clinical pregnancy rate was calculated.Results：There was no significant difference in clinical pregnancy rate between the treatment group and the control group ［46.67% (14/30) vs 33.33% (10/30)，P>0.05］.In stage 2 of treatment，the treatment group had a significant reduction in FSH and a significant increase in AFC，and the treatment group had significantly greater changes than the control group (all P<0.05).After treatment，the treatment group had significantly higher numbers of retrieved oocytes and high-quality embryos than the control group (P<0.05)，and the treatment group showed a slight increase in AMH after treatment (P>0.05).Conclusion：Warming acupuncture-moxibustion based on the theory of “vital gate，vital energy，and triple energizers” can improve the serum levels of sex hormones，ovarian function，and the pregnancy outcome of IVF-ET in patients with infertility due to DOR. |
| Key words: diminished ovarian reserve theory of “vital gate,vital energy,and triple energizers” warming acupuncture-moxibustion hormone level ovarian function in vitro fertilization-embryo transfer |
