| 摘要: |
| 目的：利用数据挖掘探讨第一和第二届国医大师辨治心系病的用药规律。方法：收集《国医大师专科专病用方经验》中治疗心系病的方剂，采用Microsoft Excel 2019、SPSS Modeler 18.0、SPSS Statistics 25.0等软件分析药物的使用规律。结果：共涉及133个治疗心系病的方剂，其中包含201种中药，频次≥20次的中药有25种；治疗心系病的药物药性以平、温为主；药味以甘、苦、辛为主；多归心、肺、脾、肝经。挖掘出治疗心系病的核心组方为归脾汤加减方。聚类分析得出4种高频药物聚类。结论：第一和第二届国医大师辨治心系病时主要使用补益药，同时根据瘀、滞、痰等标实的不同兼顾使用活血化瘀药、理气药、化痰药等，彰显了“治病求本，标本兼治”的临证治疗思想。 |
| 关键词: 心系病 国医大师 数据挖掘 用药规律 |
| DOI： |
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| Medication rule of national Chinese medicine masters of the first and second batches in syndrome differentiation-based treatment of heart system diseases：A study based on data mining |
| FENG Huike,CHEN Lingli,LI Jie |
| (The Second Affiliated Hospital of Hunan University of Chinese Medicine，Changsha 410005，Hunan，China;Hunan University of Chinese Medicine，Changsha 410208，Hunan，China) |
| Abstract: |
| Objective：To investigate the medication rule of national Chinese medicine masters of the first and second batches in the syndrome differentiation-based treatment of heart system diseases based on data mining.Methods：Related prescriptions for the treatment of heart system diseases were collected from Prescriptions for Specialty Diseases by National Chinese Medicine Masters，and Microsoft Excel 2019，SPSS Modeler 18.0，and SPSS Statistics 25.0 were used to analyze the medication rule.Results：A total of 133 prescriptions for the treatment of heart system diseases were included，involving 201 traditional Chinese medicine (TCM) drugs，and there were 25 TCM drugs with a frequency of ≥2 times.The drugs for the treatment of heart system diseases mainly had a neutral or warm nature and a sweet，bitter，or pungent taste，and they mainly entered the heart，lung，spleen，and liver meridians.The modified prescription of Guipi decoction was the core prescription for the treatment of heart system diseases.The cluster analysis obtained 4 high-frequency drug clusters.Conclusion：In the syndrome differentiation-based treatment of heart system diseases，the national Chinese medicine masters of the first and second batches mainly use tonifying drugs and consider the application of blood-activating and stasis-resolving drugs，Qi-regulating drugs，and phlegm-eliminating drugs based on the excess in superficiality such as stasis，stagnation，or phlegm，which reflects the thinking of “treatment aiming at its root causes and treating both manifestation and root cause of disease” in clinical practice. |
| Key words: heart system diseases national Chinese medicine masters data mining medication rule |
