| 摘要: |
| 目的：基于数据挖掘分析中药外用治疗急性踝关节扭伤的用药规律。方法：检索中国知网(CNKI)、万方数据(WANFANG DATA)、维普中文科技期刊数据库(VIP)自建库至2023年12月31日关于中药外用治疗急性踝关节扭伤的文献，筛选符合标准的文献及处方，进行药物使用频次、功效、性味归经、关联规则及聚类分析。结果：共筛选出有效文献185篇，纳入处方180首，涉及中药245味，使用频次排前5位的是大黄、红花、乳香、没药、当归；药物功效以活血化瘀、祛风湿、清热为主；四气以温为主，其次为寒、平；五味以辛、苦、甘为主；归经以肝、脾、心、肾经为主。关联规则分析得到19种药物组合，使用频次排前5位的依次为乳香-没药、没药-乳香、当归-红花、栀子-大黄、冰片-大黄。聚类分析得出4类药物组合。复杂网络分析表明，乳香、没药共现频次最高，其次为红花、栀子、当归、大黄、黄柏。结论：中药外用治疗急性踝关节扭伤以活血化瘀、祛风湿及清热药为主，并根据扭伤不同时期进行辨证施治，遵循筋骨并重、气血兼治的治疗原则，可为临床诊治提供一定参考。 |
| 关键词: 急性踝关节扭伤 中药外用 用药规律 数据挖掘 |
| DOI： |
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| Medication rule of traditional Chinese medicine external application in treatment of acute ankle sprain：A study based on data mining |
| LIU Xin,HE Qingjian |
| (Fujian University of Traditional Chinese Medicine，Fuzhou 350122，Fujian，China;Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine，Fuzhou 350001，Fujian，China) |
| Abstract: |
| Objective：To investigate the medication rule of traditional Chinese medicine (TCM) external application in the treatment of acute ankle sprain based on data mining.Methods：CNKI，WANFANG DATA，and VIP were searched for articles on TCM external application in the treatment of acute ankle sprain published up to December 31，2023，and the articles and prescriptions meeting related criteria were identified.The TCM drugs were analyzed in terms of frequency of use，function，nature/taste/meridian entry，association rule，and cluster analysis.Results：A total of 185 valid articles were obtained，involving 180 prescriptions and 245 TCM drugs，and the top 5 drugs in terms of frequency of use were Rheum officinale，Carthamus tinctorius，frankincense，myrrh，and Angelica sinensis.The main functions of the drugs included activating blood and resolving stasis，dispelling wind-damp，and clearing heat.Most drugs were warm in nature，followed by those with a cold or neutral nature，and most drugs had a pungent，bitter，or sweet taste; they mainly entered the liver，spleen，heart，and kidney meridians.The association rule analysis obtained 19 drug combinations，and the top 5 drug combinations in terms of frequency of use were frankincense-myrrh，myrrh-frankincense，Angelica sinensis-Carthamus tinctorius，Fructus Gardeniae-Rheum officinale，and borneol-Rheum officinale.The cluster analysis obtained 4 drug clusters.The complex network analysis showed that frankincense and myrrh had the highest frequency of co-occurrence，followed by Carthamus tinctorius，Fructus Gardeniae，Angelica sinensis，Rheum officinale，and Phellodendri Chinensis Cortex.Conclusion：blood-activating and stasis-resolving，wind-damp-dispelling，and heat-clearing drugs are mainly used in TCM external application for the treatment of acute ankle sprain，and syndrome differentiation-based treatment is performed based on the stage of sprain.This treatment method also follows the principles of emphasis on both tendon and bone and simultaneous treatment of Qi and blood，which provides a reference for clinical diagnosis and treatment. |
| Key words: acute ankle sprain traditional Chinese medicine external application medication rule data mining |
