| 摘要: |
| 目的:观察抑囊助孕汤治疗多囊卵巢综合征伴胰岛素抵抗（PCOS-IR）脾虚痰湿证的临床疗效。方法：选取PCOS-IR患者60例，将其随机分为治疗组和对照组，每组各30例。对照组予地屈孕酮合二甲双胍治疗，治疗组在对照组基础上加用抑囊助孕汤治疗，疗程均为3个月经周期。比较2组治疗前后体质量指数(BMI)、性激素指标［睾酮(T)、促卵泡生成素(FSH)、黄体生成素(LH)、LH/FSH比值］、IR相关指标［空腹胰岛素(FINS)、空腹血糖(FBG)、胰岛素抵抗指数（HOMA-IR）］、及中医证候积分。结果：治疗后2组BMI、T、LH、LH/FSH、FINS、FBG、HOMA-IR、中医证候积分均较治疗前下降，且治疗组低于对照组(P<0.05或P<0.01)；2组血清FSH治疗前后均无明显变化 (P＞0.05)。结论：抑囊助孕汤联合二甲双胍、地屈孕酮治疗PCOS-IR可改善女性生殖内分泌失调状态，降低BMI，改善糖代谢异常及胰岛素抵抗状态。 |
| 关键词: 多囊卵巢综合征 胰岛素抵抗 健脾祛湿法 抑囊助孕汤 |
| DOI： |
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| Clinical effect of Yinang Zhuyun decoction in treatment of polycystic ovary syndrome with insulin resistance with the syndrome of spleen deficiency and phlegm-dampness：An analysis of 30 cases |
| GAO Xiaohan,WANG Xin |
| (Liaoning University of Traditional Chinese Medicine，Shenyang 110847，Liaoning，China;The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110847，Liaoning，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Yinang Zhuyun decoction in the treatment of polycystic ovary syndrome with insulin resistance (PCOS-IR) with the syndrome of spleen deficiency and phlegm-dampness.Methods：A total of 60 patients with PCOS-IR were randomly divided into treatment group and control group，with 30 patients in each group.The patients in the control group were given dydrogesterone combined with metformin，while those in the treatment group were given Yinang Zhuyun decoction in addition to the treatment in the control group; the course of treatment was 3 menstrual cycles for both groups.The two groups were compared in terms of body mass index (BMI)，sex hormone indicators ［testosterone (T)，follicle-stimulating hormone (FSH)，luteinizing hormone (LH)，and LH/FSH ratio］，IR indicators ［fasting insulin (FINS)，fasting blood glucose (FBG)，and homeostasis model assessment of insulin resistance (HOMA-IR)］，and traditional Chinese medicine (TCM) syndrome score before and after treatment.Results：After treatment，both groups had significant reductions in BMI，T，LH，LH/FSH ratio，FINS，FBG，HOMA-IR，and TCM syndrome score，and the treatment group had significantly lower values than the control group (P<0.05 or P<0.01); there was no significant change in serum FSH in either group after treatment (P > 0.05).Conclusion：Yinang Zhuyun decoction combined with metformin and dydrogesterone for the treatment of PCOS-IR can improve reproductive endocrine disorders，reduce BMI，and improve abnormal glucose metabolism and insulin resistance. |
| Key words: polycystic ovary syndrome insulin resistance spleen-invigorating and dampness-eliminating therapy Yinang Zhuyun decoction |
