| 摘要: |
| 目的：基于数据挖掘探析徐瑞荣教授治疗弥漫大B细胞淋巴瘤的用药规律。方法：收集2021年9月1日至2023年9月1日徐瑞荣教授治疗弥漫大B细胞淋巴瘤的门诊中药处方，进行临床资料整理并建立数据库，运用古今医案云平台对筛选出的中药处方进行药物频次统计、性味归经统计、关联分析、聚类分析和复杂网络分析。结果：共纳入中药处方208首，涉及中药229味，药物使用总频次为3 916次，高频用药包括山慈菇、陈皮、干姜、醋鸡内金、黄芩、甘草、延胡索、川楝子、红参、川芎等，药性多为温、寒、平，药味多为甘、苦、辛，主要归脾、肝、肺经。药物关联中高频药物组合为干姜与清半夏、黄芩与陈皮、延胡索与川楝子等。聚类分析将药物聚为5类。复杂网络分析显示核心处方由陈皮、清半夏、山慈菇、干姜、黄芩等9味中药组成。结论：徐瑞荣教授认为弥漫大B细胞淋巴瘤为正虚毒蕴、气郁痰瘀所致的虚实夹杂之证，其以治痰、治气、治火为主要原则，选用清热解毒、燥湿化痰、理气健脾的中药辨证施治。 |
| 关键词: 弥漫大B细胞淋巴瘤 数据挖掘 用药规律 徐瑞荣 |
| DOI： |
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| Medication rule of Xu Ruirong in treatment of diffuse large B-cell lymphoma：A study based on data mining |
| GAO Chang,WANG Teng,LYU Chunyi |
| (The First Clinical Medical College of Shandong University of Traditional Chinese Medicine，Jinan 250014，Shandong，China) |
| Abstract: |
| Objective：To investigate the medication rule of Xu Ruirong in the treatment of diffuse large B-cell lymphoma based on data mining.Methods：Traditional Chinese medicine (TCM) prescriptions were collected from the patients treated by Professor Xu Ruirong at the outpatient service from September 1，2021 to September 1，2023，and clinical data were collected to establish a database.Cloud Platform of Ancient and Modern Medical Records was used to analyze the TCM prescriptions in terms of drug frequency and nature/taste/meridian entry，and the association analysis，the cluster analysis，and the complex network analysis were also performed.Results：A total of 208 TCM prescriptions were included，involving 229 TCM drugs，with a total frequency of drug use of 3 916 times.High-frequency drugs included Cremastrae Pseudobulbus，tangerine peel，dried ginger，vinegar-processed Chicken’s Gizzard-membrane，Scutellaria baicalensis，Radix Glycyrrhizae，Rhizoma Corydalis，Szechwan chinaberry fruit，red ginseng，and Rhizoma Chuanxiong.Most drugs were warm，cold or neutral in nature and had a sweet，bitter or pungent taste，and the drugs mainly entered the spleen，liver，and lung meridians.The drug association analysis obtained the high-frequency drug combinations of dried ginger-Rhizoma Pinelliae Preparata，Scutellaria baicalensis-tangerine peel，and Rhizoma Corydalis-Szechwan chinaberry fruit.Five clusters of drugs were obtained by the cluster analysis.The complex network analysis showed that the core prescription was composed of 9 TCM drugs such as tangerine peel，Rhizoma Pinelliae Preparata，Cremastrae Pseudobulbus，dried ginger，and Scutellaria baicalensis.Conclusion：Professor Xu Ruirong believes that diffuse large B-cell lymphoma is a syndrome with both deficiency and excess caused by weakened body resistance，toxic accumulation，Qi depression，and phlegm stasis，and the principle of treating phlegm，Qi，and fire should be applied.TCM drugs for clearing heat and detoxicating，drying dampness and resolving phlegm，and regulating Qi and strengthening the spleen should be applied based on syndrome differentiation. |
| Key words: diffuse large B-cell lymphoma data mining medication rule Xu Ruirong |
