| 摘要: |
| 目的：基于数据挖掘分析《中华医典》中治疗少弱精子症处方的用药规律。方法：收集《中华医典》数据库中治疗本病的处方，通过Excel 2021建立处方数据库，并对处方中出现的药物进行频次统计分析；用SPSS Modeler 18.0软件对处方中出现的药物进行关联规则分析；通过SPSS Statistics 26.0软件对高频药物进行系统聚类分析。结果：总计录入120首处方，涉及227味中药，补虚药占比最高（73味，32.16%），菟丝子出现频率最高（59次，3.70%），药性以温、平为主，药味以甘、辛多见，归经主要涉及肾、肝、脾经。关联分析显示肉苁蓉-蛇床子，山药、肉苁蓉-五味子，山茱萸、熟地黄-山药关联度最高。聚类分析发现6个新处方。结论：《中华医典》中治疗少弱精子症的处方组方原则以补虚为主，重用补肾温阳之品，辅以健脾益气，同时兼顾燥湿化痰、活血祛瘀、收敛固涩，标本同治，攻补兼施。 |
| 关键词: 少弱精子症 《中华医典》 数据挖掘 用药规律 |
| DOI： |
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| Medication rule in prescriptions for the treatment of oligospermia/asthenozoospermia in Chinese Medical Canon：A study based on data mining |
| LIU Yunlu,MU Youyou,LI Huijun |
| (Guizhou University of Traditional Chinese Medicine，Guiyang 550002，Guizhou，China) |
| Abstract: |
| Objective：To investigate the medication rule in prescriptions for the treatment of oligospermia/asthenozoospermia in Chinese Medical Canon based on data mining.Methods：Related prescriptions for the treatment of this disease were collected from Chinese Medical Canon database.Excel 2021 was used to establish a database for these prescriptions，and the frequency of drugs in the prescriptions was analyzed.SPSS Modeler 18.0 was used to perform an association rule analysis of drugs in the prescriptions，and SPSS Statistics 26.0 was used to perform a hierarchical cluster analysis of high-frequency drugs.Results：A total of 120 prescriptions were included，involving 227 traditional Chinese medicine drugs，among which deficiency-tonifying herbs accounted for the highest proportion of 32.16% (73 herbs)，and China dodder seed had the highest frequency of 59 times (3.70%).Most drugs were warm or neutral in nature and had a sweet or pungent taste，and the drug mainly entered the kidney，liver，and spleen meridians.The association analysis showed the highest degree of association between Cistanche deserticola and Fructus Cnidii，between Dioscorea opposite/Cistanche deserticola and Schisandra chinensis，and between Comus officinalis/prepared Radix Rehmanniae and Dioscorea opposite.The cluster analysis obtained 6 new prescriptions.Conclusion：The prescriptions for the treatment of oligospermia/asthenozoospermia in Chinese Medical Canon have the prescription rule of tonifying deficiency and emphasizing the application of kidney-tonifying and Yang-warming drugs，supplemented by the drugs for strengthening the spleen and benefiting Qi，with consideration to dampness-drying and phlegm-eliminating drugs，blood-activating and blood stasis-removing drugs，and astringent drugs，as well as the principles of simultaneous treatment of principal and subordinate symptoms and tonification and purgation in combination. |
| Key words: oligospermia/asthenozoospermia Chinese Medical Canon data mining medication rule |
