| 摘要: |
| 目的：应用数据挖掘方法研究程丑夫教授治疗心力衰竭的用药经验。方法：收集整理2021年9月1日至2024年1月1日程教授门诊病历，通过中医传承辅助平台软件（V2.5）对其所使用药物进行频数、关联、聚类分析。 结果：共收集程教授治疗心力衰竭的处方142首，所用药物药性以温寒平为主，药味以甘、苦、辛味居多，归经中脾经居于首位，其次为肺、胃、心经，高频药物包括党参、法半夏、黄芪、五味子、黄连、生姜、砂仁、甘草、木香、麦冬。通过组方规律分析得到常用药物组合14个，其中有9个置信度>0.95的组合，3个置信度>1的组合，得出治疗心力衰竭的常用药物包括党参、黄芪、甘草、醋五味子、黄连、法半夏、生姜、麦冬、砂仁。通过药物聚类分析得到9个核心药物组合。结论：程教授治疗心力衰竭重视调气、用药平和，善用补虚药，临证多用生脉陷胸汤（生脉散、小陷胸汤）合丹参饮加减。 |
| 关键词: 心力衰竭 数据挖掘 用药规律 程丑夫 |
| DOI： |
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| Medication experience of Cheng Choufu in treatment of heart failure：A study based on data mining |
| WU Chengquan,ZHANG Weining |
| (The First Affiliated Hospital of Hunan University of Chinese Medicine，Changsha 410007，Hunan，China;Yantian People’s Hospital，Shenzhen 518081，Guangdong，China) |
| Abstract: |
| Objective：To investigate the medication experience of Professor Cheng Choufu in the treatment of heart failure based on data mining.Methods：Medical records were collected from the patients treated by Professor Cheng at the outpatient service from September 1，2021 to January 1，2024，and Traditional Chinese Medicine Inheritance Support System (V2.5) was used to perform frequency，association，and cluster analyses of the drugs used.Results：A total of 142 prescriptions used by Professor for the treatment of heart failure were collected.Most drugs used were warm，cold or neutral in nature and had a sweet，bitter or pungent taste，and most drugs entered the spleen meridian，followed by the lung，stomach，and heart meridians.High-frequency drugs included Codonopsis pilosula，Rhizoma Pinelliae Praeparatum，Astragalus membranaceus，Schisandra chinensis，Coptis chinensis，ginger，Amomum villosum，Radix Glycyrrhizae，Saussurea costus，and Radix Ophiopogonis.The prescription rule analysis obtained 14 commonly used drug combinations，among which 9 combinations had a reliability of >0.95 and 3 combinations had a reliability of >1，and the drugs commonly used for the treatment of heart failure included Codonopsis pilosula，Astragalus membranaceus，Radix Glycyrrhizae，venigar-processed Schisandra chinensis，Coptis chinensis，Rhizoma Pinelliae Praeparatum，ginger，Radix Ophiopogonis，and Amomum villosum.The cluster analysis obtained 9 core drug combinations.Conclusion：Professor Cheng emphasizes the regulation of Qi and the application of neutral drugs in the treatment of heart failure and often uses deficiency-tonifying herbs.Shengmai Xianxiong decoction (Shengmai powder and Xiaoxianxiong decoction) combined with modified Danshen decoction is commonly used in clinical practice. |
| Key words: heart failure data mining medication rule Cheng Choufu |
