| 摘要: |
| 目的：观察芪连结肠宁汤联合耳穴贴压治疗慢性复发型溃疡性结肠炎脾虚湿蕴证的临床疗效。方法:将56例慢性复发型溃疡性结肠炎脾虚湿蕴证患者随机分为治疗组和对照组，每组各28例。对照组予以美沙拉嗪肠溶片治疗，治疗组在对照组的基础上加服芪连结肠宁汤联合耳穴贴压治疗。治疗4周后、8周后，比较2组临床有效率、临床缓解率、粪便钙卫蛋白（FC）转阴率；治疗8周后，比较2组治疗前后改良梅奥(Mayo)评分、中医证候评分，并观察不良反应发生情况。结果:治疗4周后，临床有效率、临床缓解率、FC转阴率治疗组分别为53.57%（15/28）、32.14%（9/28）、28.57%（8/28），对照组分别为32.14%（9/28）、7.14%（2/28）、7.14%（2/28），2组比较,差异均有统计学意义(P<0.05)。治疗8周后，临床有效率、临床缓解率、FC转阴率治疗组分别为92.86%（26/28）、82.14%（23/28）、67.86%（19/28），对照组分别为71.43%（20/28）、57.14%（16/28）、39.29%（11/28），2组比较,差异均有统计学意义(P<0.05)。2组Mayo评分、中医证候评分治疗前后组内比较及治疗后组间比较，差异均有统计学意义（P＜0.05或P＜0.01）。治疗后，不良反应发生率治疗组为7.14%（2/28），对照组为17.85%（5/28），2组比较，差异有统计学意义（P＜0.05）。结论：芪连结肠宁汤联合耳穴贴压治疗慢性复发型溃疡性结肠炎脾虚湿蕴证疗效较佳，能有效减少患者腹泻及脓血便的次数，减轻腹痛，较好地改善食少、肢体困倦等症状，值得临床推广应用。 |
| 关键词: 溃疡性结肠炎 脾虚湿蕴证 芪连结肠宁 耳穴贴压 |
| DOI： |
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| Clinical effect of Qilian Jiechangning decoction combined with auricular point sticking in treatment of chronic recurrent ulcerative colitis with spleen deficiency and dampness stagnation: An analysis of 28 cases |
| HU Jinyang,JIANG Shisheng,NIU Junjie |
| (Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Changsha 410006,Hunan,China) |
| Abstract: |
| Objective：To investigate the clinical effect of Qilian Jiechangning decoction combined with auricular point sticking in the treatment of chronic recurrent ulcerative colitis with spleen deficiency and dampness stagnation.Methods: A total of 56 patients with chronic recurrent ulcerative colitis with spleen deficiency and dampness stagnation were randomly divided into treatment group and control group,with 28 patients in each group.The patients in the control group received mesalazine enteric-coated tablets,and those in the treatment group received Qilian Jiechangning decoction combined with auricular point sticking in addition to the treatment in the control group.After 4 and 8 weeks of treatment,the two groups were compared in terms of clinical response rate,clinical remission rate,and fecal calprotectin (FC) clearance rate；after 8 weeks of treatment,the two groups were compared in terms of modified Mayo score,traditional Chinese medicine (TCM) syndrome score,and adverse reactions.Results: After 4 weeks of treatment,the treatment group had a clinical response rate of 53.57% (15/28),a clinical remission rate of 32.14% (9/28),and an FC clearance rate of 28.57% (8/28),while the control group had a clinical response rate of 32.14% (9/28),a clinical remission rate of 7.14% (2/28),and an FC clearance rate of 7.14% (2/28),and there were significant differences between the two groups (P<0.05).After 8 weeks of treatment,the treatment group had a clinical response rate of 92.86% (26/28),a clinical remission rate of 82.14% (23/28),and an FC clearance rate of 67.86% (19/28),while the control group had a clinical response rate of 71.43% (20/28),a clinical remission rate of 57.14% (16/28),and an FC clearance rate of 39.29% (11/28)；there were significant differences between the two groups (P<0.05).Both groups had significant changes in Mayo score and TCM syndrome score after treatment,and there were significant differences in these scores between the two groups after treatment (P<0.05 or P< 0.01).After treatment,there was a significant difference in the incidence rate of adverse reactions between the treatment group and the control group ［7.14% (2/28) vs 17.85% (5/28),P<0.05］.Conclusion: Qilian Jiechangning combined with auricular point sticking had a good clinical effect in the treatment of chronic recurrent ulcerative colitis with spleen deficiency and dampness stagnation and can effectively reduce the number of times of diarrhea and stool with blood and pus,alleviate abdominal pain,and improve the symptoms such as poor appetite and limb fatigue,and therefore,it holds promise for clinical application. |
| Key words: chronic recurrent ulcerative colitis spleen deficiency and dampness stagnation Qilian Jiechangning decoction auricular point sticking |
