| 摘要: |
| 目的：分析杨鉴冰教授运用中医药治疗早发性卵巢功能不全(POI)的用药规律。方法：收集杨教授治疗POI的门诊处方，录入中医传承辅助平台(V2.5）软件，采用该软件集成的Apriori关联规则分析、熵层次聚类等数据挖掘方法，分析杨教授治疗POI的中医药处方。结果：在筛选出的92个处方中，涉及中药126味，其中频次≥30次的药物25味，药性以温、平性为主，药味多为甘、苦、辛味；归经多为肾、肝、脾经；使用频率最高的是补虚药、活血化瘀药和理气药；应用关联规则提取到16对常用药对，聚类分析得到5个核心处方。结论：杨教授治疗POI用药主要为补肾填精、养血活血，常辅以健脾理气、疏肝解郁等药物，体现了其从肾虚血瘀辨治POI的主要学术思想。 |
| 关键词: 早发性卵巢功能不全 数据挖掘 中医药治疗 用药规律 杨鉴冰 |
| DOI： |
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| Medication rule of Yang Jianbing in treatment of premature ovarian insufficiency: A study based on data mining |
| QU Xiaohui,HE Wei,MA Meng |
| (The Second Affiliated Hospital of Shaanxi University of Chinese Medicine，Xianyang 712000，Shaanxi，China;Shaanxi University of Chinese Medicine，Xianyang 712046，Shaanxi，China) |
| Abstract: |
| Objective: To investigate the medication rule of Professor Yang Jianbing in the traditional Chinese medicine (TCM) treatment of premature ovarian insufficiency (POI) based on data mining.Methods: Outpatient prescriptions were collected from the cases treated by Professor Yang and were then entered into Traditional Chinese Medicine Inheritance Support System (V2.5) software，and the data mining methods in this software，such as Apriori association rule analysis and entropy-based hierarchical clustering，were used to analyze the TCM prescriptions used by Professor Yang in the treatment of POI.Results: A total of 92 prescriptions were obtained，involving 126 TCM drugs，among which 25 TCM drugs had a frequency of ≥30.Most drugs were warm or neutral in nature and had a sweet，bitter or pungent taste，and they mainly entered the kidney，liver，and spleen meridians.Deficiency-tonifying drugs，blood-activating and stasis-resolving drugs，and Qi-regulating drugs showed the highest frequency of use.The association rule analysis obtained 16 commonly used drug combinations，and the cluster analysis obtained 5 core prescriptions.Conclusion: The TCM drugs used by Professor Yang in the treatment of POI mainly have the functions of nourishing kidney-essence，nourishing the blood，and activating the blood，often in combination with the drugs for strengthening the spleen，regulating Qi，soothing the liver，and resolving stagnation，which reflects the academic thinking of syndrome differentiation-based treatment of POI from the perspective of kidney deficiency and blood stasis. |
| Key words: premature ovarian insufficiency data mining traditional Chinese medicine treatment medication rule Yang Jianbing |
