| 摘要: |
| 目的：观察加味寿胎丸联合地屈孕酮对肾虚型早期先兆流产患者保胎后妊娠结局的影响。方法：将肾虚型早期先兆流产患者92 例按随机数字表法分为治疗组和对照组，每组各46 例。对照组采用地屈孕酮治疗，治疗组在对照组基础上加用加味寿胎丸治疗。治疗14 d后，比较2组中医证候积分，子宫动脉血流参数［动脉阻力指数（RI）、搏动指数（PI）］，性激素水平［人绒毛膜促性腺激素（β-hCG）、孕酮（P）、雌二醇（E2）］及妊娠结局。结果：总有效率治疗组为89.13%（41/46），对照组为69.57%（32/46），2组比较，差异有统计学意义（P<0.05）。治疗组的阴道流血量、流血时间、流血色质、下腹部疼痛或坠胀、腰膝酸软等中医证候积分，RI、PI、β-hCG、P、E2水平与对照组比较，差异均有统计学意义（P<0.05）。保胎成功率治疗组为95.65%（44/46），对照组为80.43%（37/46），2组比较，差异有统计学意义（P<0.05）。结论：加味寿胎丸联合地屈孕酮治疗肾虚型早期先兆流产效果确切，能明显缓解临床症状，改善患者子宫动脉血流参数和性激素水平，提高保胎成功率。 |
| 关键词: 早期先兆流产 肾虚型 加味寿胎丸 地屈孕酮 妊娠结局 |
| DOI： |
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| Effect of Jiawei Shoutai pills combined with dydrogesterone on pregnancy outcome of kidney-deficiency early threatened abortion after tocolytic therapy |
| ZHAO Ziyi,ZHANG Jincong,LI Yafang |
| (Luohe Hospital of Traditional Chinese Medicine，Luohe 462000，Henan，China) |
| Abstract: |
| Objective：To investigate the effect of Jiawei Shoutai pills combined with dydrogesterone on the pregnancy outcome of kidney-deficiency early threatened abortion after tocolytic therapy.Methods：A total of 92 patients with kidney-deficiency early threatened abortion were divided into treatment group and control group using a random number table，with 46 patients in each group.The patients in the control group were given dydrogesterone，and those in the treatment group were given Jiawei Shoutai pills in addition to the treatment in the control group.After 14 days of treatment，the two groups were compared in terms of traditional Chinese medicine (TCM) syndrome score，uterine artery blood flow parameters ［resistance index （RI） and pulsatility index （PI） of the uterine artery］，sex hormone levels ［β-human chorionic gonadotrophin （β-hCG），progesterone （P），and estradiol （E2)］，and pregnancy outcome.Results：There was a significant difference in overall response rate between the treatment group and the control group ［89.13% (41/46) vs 69.57% (32/46)，P<0.05］.There were significant differences between the two groups in TCM syndrome score (such as vaginal bleeding volume，bleeding time，color of bleeding，lower abdominal pain or bulge，soreness and weakness of the waist and knees)，RI，PI，and levels of β-hCG，P，and E2 (P<0.05).There was a significant difference in the success rate of tocolytic therapy between the treatment group and the control group ［95.65% (44/46) vs 80.43% (37/46)，P<0.05］.Conclusion：Jiawei Shoutai pills combined with dydrogesterone has a marked clinical effect in the treatment of kidney-deficiency early threatened abortion and can significantly alleviate clinical symptoms，improve uterine artery blood flow parameters and sex hormone levels，and increase the success rate of tocolytic therapy. |
| Key words: early threatened abortion kidney-deficiency Jiawei Shoutai pills dydrogesterone pregnancy outcome |
