| 摘要: |
| 目的：研究金元四大家治疗水肿的用药规律。方法：收集金元四大家医学著作中治疗水肿的中药处方,利用WPS Excel 软件建立方药数据库,应用SPSS 20.0、IBM SPSS Modeler 18.0、Cytoscape统计软件进行中药的频数、性味、归经分析,对高频中药进行功效、因子、关联规则分析及核心中药网络分析。结果：共获得处方64首,中药120味。中药总使用频次为502次,高频中药16味,排前5位的中药依次为陈皮、茯苓、泽泻、白术、牵牛子。高频中药排前3位的功效依次为利水渗湿、峻下逐水、理气。中药四气以寒、温、平性为主,五味以苦、甘、辛味为主,归经以脾、肾、肺经为主。因子分析共得到中药组合类方5组。关联规则分析中,支持度最高的药对为茯苓-白术、茯苓-泽泻,药组为大戟-芜花-甘遂、甘草-茯苓-白术,泽泻-茯苓-白术,陈皮-茯苓-白术。核心中药网络分析得到2组核心组方。结论：金元四大家治疗水肿主要从脾、肾、肺三脏论治,病机以脾虚湿盛、湿热内蕴、气滞湿阻、肺失宣肃为主,治法以健脾化湿、培土制水、清热化湿、利水消肿、峻下逐水、泻肺利水为主,常用方剂有神佑丸、白术木香散、葶苈木香散、胃苓汤等。 |
| 关键词: 金元四大家 刘完素 李东垣 张子和 朱丹溪 水肿 用药规律 |
| DOI： |
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| Mediation rule of the four great medical schools in Jin and Yuan Dynasties in treatment of edema |
| WU Zijian,GUO Xiaohui,ZHANG Renguo |
| (Zigong Hospital of Traditional Chinese Medicine,Zigong 643010,Sichuan,China) |
| Abstract: |
| Objective：To investigate the mediation rule of the four great medical schools in Jin and Yuan Dynasties in the treatment of edema.Methods：Traditional Chinese medicine (TCM) prescriptions for the treatment of edema were collected from the works of the four great medical schools in Jin and Yuan Dynasties.WPS Excel software was used to establish a prescription-drug database,and SPSS 20.0,IBM SPSS Modeler 18.0,and Cytoscape statistical software were used to analyze the frequency,taste and flavor,and meridian entry of TCM drugs.Function analysis,factor analysis,association rule analysis,and core TCM drug network analysis were performed for high-frequency TCM drugs.Results：A total of 64 prescriptions were obtained,involving 120 TCM drugs.The TCM drugs had a total frequency of 502,and there were 16 high-frequency TCM drugs,with the top 5 drugs of tangerine peel,Poria cocos,Alisma orientalis,Atractylodes macrocephala Koidz.,and Semen Pharbitidis.The top three functions of the high-frequency TCM drugs were promoting diuresis and draining dampness,drastically purging and expelling the excessive fluid,and regulating Qi.Most drugs were cold,warm or neutral in nature,had a bitter,sweet or pungent taste,and entered the spleen,kidney,and lung meridians.Factor analysis obtained five combinations of TCM drugs.Association rule analysis showed that the drug pair of Poria cocos-Atractylodes macrocephala Koidz.and poria cocos-Alisma orientalis had the highest degree of support,and the drug combinations of Euphorbia pekinensis-Flos Genkwa-Euphorbia kansui,Radix Glycyrrhizae-Poria cocos-Atractylodes macrocephala Koidz.,Alisma orientalis-Poria cocos-Atractylodes macrocephala Koidz.,and tangerine peel-Poria cocos-Atractylodes macrocephala Koidz.had the highest degree of support.The core TCM drug network analysis obtained two core drug prescriptions.Conclusion：The four great medical schools in Jin and Yuan Dynasties treated edema mainly from the three visceral organs of the spleen,the kidneys,and the lungs.The main pathogenesis of edema includes spleen deficiency and dampness excess,internal retention of damp-heat,Qi stagnation and damp obstruction,and failure of the lungs to regulate diffusion and purification,and the main treatment methods include spleen-strengthening and dampness-removing therapy,kidney-warming and spleen-invigorating therapy,heat-clearing and dampness-resolving therapy,diuresis-inducing and edema-alleviating therapy,the therapy of drastically purging and expelling the excessive fluid,and lung-purging and diuresis-inducing therapy.Commonly used prescriptions include Shenyou pills,Baizhu Muxiang powder,Tingli Muxiang powder,and Weiling decoction. |
| Key words: four great medical schools in Jin and Yuan Dynasties Liu Wansu Li Dongyuan Zhang Zihe Zhu Danxi edema medication rule |
