| 摘要: |
| 目的：探讨清金化瘀汤治疗急性放射性肺炎的临床疗效及对患者血浆炎症因子、血清降钙素原（PCT）及超敏C-反应蛋白（hs-CRP）的影响。方法：将72例急性放射性肺炎患者随机分为2组，每组各36例。对照组给予泼尼松治疗，治疗组在此基础上给予清金化瘀汤治疗。观察2组治疗前后中医症状改善情况并评估临床疗效，检测血浆炎症因子白介素-1α（IL-1α）、白介素-6（IL-6）、转化生长因子-β（TGF-β）水平，PCT及hs-CRP的含量。结果：综合疗效总有效率治疗组为88.89%、对照组为77.78%，呼吸困难评分改善率治疗组为63.89%、对照组为16.67%，KPS评分提高率治疗组为44.44%、对照组为27.78%，以上3项组间比较，差异均有统计学意义（P＜0.05）；与治疗前比较，2组血浆PCT、hs-CRP及炎症因子IL-1α、IL-6、TGF-β水平均降低（P＜0.05），组间比较，PCT、hs-CRP差异无统计学意义（P>0.05），IL-1α、IL-6、TGF-β差异则有统计学意义（P＜0.05）。结论：清金化瘀汤可有效治疗急性放射性肺炎，并改善患者生活质量，提高临床疗效，其机制与促进血浆中炎症因子IL-1α、IL-6、TGF-β水平降低有关。 |
| 关键词: 放射性肺炎 清金化瘀汤 炎症因子 |
| DOI： |
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| Clinical effect of Qingjin Huayu decoction in treatment of acute radiation pneumonitis and its influence on inflammatory factors |
| ZENG Weiyu,TIAN Xuefei,DENG Zhe |
| (Clinical Medical College，Hunan University of Chinese Medicine，Changsha 410208，Hunan，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Qingjin Huayu decoction in the treatment of acute radiation pneumonitis and its influence on plasma inflammatory factors，serum procalcitonin (PCT)，and high-sensitivity C-reactive protein (hs-CRP).Methods：A total of 72 patients with acute radiation pneumonitis were randomly divided into treatment group and control group，with 36 patients in each group.The patients in the control group were given prednisone，and those in the treatment group were given Qingjin Huayu decoction in addition to the treatment in the control group.The two groups were observed in terms of the improvement in traditional Chinese medicine (TCM) symptoms and clinical outcome after treatment，and the plasma levels of related inflammatory factors ［interleukin-1α (IL-1α)，interleukin-6 (IL-6)，and transforming growth factor-β (TGF-β)］，PCT，and hs-CRP were measured.Results：There were significant differences between the treatment group and the control group in overall response rate (88.89% vs 77.78%，P＜0.05)，improvement rate of dyspnea score (63.89% vs 16.67%，P＜0.05)，and rate of increase in Karnofsky Performance Scale score (44.44% vs 27.78%，P＜0.05).Both groups had significant reductions in PCT，hs-CRP，and the inflammatory factors IL-1α，IL-6，and TGF-β after treatment；there were no significant differences in PCT and hs-CRP between the two groups (P>0.05)，while there were significant differences in IL-1α，IL-6，and TGF-β between the two groups(P＜0.05).Conclusion：Qingjin Huayu decoction has a good clinical effect in the treatment of acute radiation pneumonitis and can improve patients’ quality of life and clinical outcome，possibly by reducing the plasma levels of IL-1α，IL-6，and TGF-β. |
| Key words: radiation pneumonitis Qingjin Huayu decoction inflammatory factor |
