| 摘要: |
| 目的:观察四逆汤对高脂血症(HLP）动脉粥样硬化(AS）兔血清血管内皮生长因子(VEGF）、基质细胞衍生因子1(SDF-1）表达的影响。方法：新西兰大耳白兔60只，随机分为6组，每组10只，即空白对照组（A组）、AS模型组（B组）、阿托伐他汀组（C组）、四逆汤低剂量组（D组）、四逆汤中剂量组（E组）、四逆汤高剂量组（F组）。兔HLP合并AS模型的建立采用高脂饲料喂养法，C、D、E、F组分别给予阿托伐他汀和四逆汤（高、中、低剂量）干预。12周后行主动脉切片HE染色观察，并检测所取兔血中VEGF和SDF-1水平。结果：与模型组比较，四逆汤高、中剂量组家兔血清VEGF和SDF-1水平降低，差异均有统计学意义(P<0.01）。结论：四逆汤可能对HLP合并AS兔的血管内皮有保护作用，从而降低VEGF和SDF-1水平。 |
| 关键词: 高脂血症 动脉粥样硬化 四逆汤 血管内皮生长因子 基质细胞衍生因子1 实验研究 |
| DOI： |
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| Effect of Sini decoction on stromal cell-derived factor-1 and vascular endothelial growth factor in rabbits with experimental hyperlipidemia complicated by atherosclerosis |
| HUANG Zhen,YU Bao-sheng,JU Shi-cong |
| (Hunan University of Chinese Medicine，Changsha 410208，Hunan，China) |
| Abstract: |
| Objective：To investigate the effect of Sini decoction on the expression of vascular endothelial growth factor（VEGF）and stromal cell-derived factor-1（SDF-1）in serum in rabbits with hyperlipidemia（HLP）complicated by atherosclerosis（AS）.Methods：A total of 60 New Zealand big-eared white rabbits were randomly divided into blank control group（group A），AS model group（group B），atorvastatin group（group C），low-dose Sini decoction group（group D），middle-dose Sini decoction group（group E），and high-dose Sini decoction group（group F），with 10 rabbits in each group.The rabbits were given high-fat feed to establish a model of HLP complicated by AS，and the rabbits in groups C，D，E，and F were treated with atorvastatin and high-，middle-，and low-dose Sini decoction，respectively.After 12 weeks of intervention，HE staining was performed for aortic sections，and blood samples were collected to measure the serum levels of VEGF and SDF-1.Results：Compared with the model group，the high- and middle-dose Sini decoction groups had significant reductions in the serum levels of VEGF and SDF-1（P<0.01）.Conclusion：Sini decoction has a protective effect on the vascular endothelium and can reduce the levels of VEGF and SDF-1 in rabbits with HLP complicated by AS. |
| Key words: hyperlipidemia atherosclerosis Sini decoction vascular endothelial growth factor stromal cell-derived factor-1 experimental study |
