| 摘要: |
| 目的：观察白地洗剂通过调节辅助性T 细胞1 型（T helper 1 cell，Th1）/ 辅助性T 细胞2 型（T
helper 2 cell，Th2）平衡和抑制皮肤炎症反应治疗特应性皮炎（atopic dermatitis， AD）湿热蕴肤证的临床疗效。
方法：选取60 例AD 湿热蕴肤证患者，将其随机分为治疗组和对照组，每组各30 例。2 组患者均口服枸地氯
雷他定片，治疗组予以白地洗剂外洗，对照组予以高锰酸钾溶液外洗，均连续治疗2 周，观察2 组治疗前后特
应性皮炎评分（SCORing Atopic Dermatitis index，SCORAD）、瘙痒视觉模拟量表（Visual Analogue Scale，VAS）
评分，皮肤病生活质量指数评分（dermatology life quality index， DLQI）及外周免疫球蛋白（immunoglobulin E，
IgE）、Th1、Th2、Th1/Th2 水平，并评价临床疗效、记录不良反应发生情况。结果：总有效率治疗组为96.67%
（29/30），对照组为70.00%（21/30），2 组比较，差异有统计学意义（P <0.05）。2 组SCORAD、瘙痒VAS、DLQI
评分和Ig E、Th1、Th2、Th1/Th2 治疗前后组内比较及治疗后组间比较，差异均有统计学意义（P <0.05）。2
组治疗期间均未发生不良反应。结论：白地洗剂治疗AD 湿热蕴肤证的临床疗效显著，能够有效降低患者
SCORAD、VAS、DLQI 评分和IgE 水平，并显著改善患者生活质量，抑制特应性皮炎的炎症反应，快速控制瘙痒，
其作用机制可能与调节Th1/Th2 免疫失衡相关。 |
| 关键词: 特应性皮炎 湿热蕴肤证 白地洗剂 高锰酸钾 枸地氯雷他定 |
| DOI： |
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| Clinical effect of Baidi lotion in treatment of atopic dermatitis with damp-heat accumulation in theskin: An analysis of 30 cases |
| LIANG Xuanran,YANG Dengke,XU Jinrui,ZHANG Shaodan,LI Wenyao,ZHU Yuandan,LONG Lixian,WU Jie |
| (Yunnan University of Chinese Medicine, Kunming 650500, Yunnan, China;Kunming Hospital of Traditional Chinese Medicine, Kunming 650599, Yunnan, China;Kunming Hospital of Traditional Chinese Medicine, Kunming 650599, Yunnan, China;Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian, China) |
| Abstract: |
| Objective: To investigate the application of Baidi lotion in the treatment of atopic dermatitis （AD） by
regulating T helper type 1 （Th1）/T helper type 2 （Th2） balance and inhibiting skin inflammatory response. Methods:A total of 60 AD patients with damp-heat accumulation in the skin were enrolled and randomly divided into treatment group
and control group, with 30 patients in each group. In addition to the oral administration of desloratadine citrate disodium
tablets, the patients in the treatment group received external washing with Baidi lotion, while those in the control group
received external washing with potassium permanganate solution, and the course of treatment was 2 consecutive weeks for
both groups. The two groups were observed in terms of Scoring Atopic Dermatitis （SCORAD）, Visual Analogue Scale
（VAS） score for pruritus, Dermatology Life Quality Index （DLQI） score, and the levels of immunoglobulin E （IgE）,
Th1, Th2, and Th1/Th2 ratio in peripheral blood. Clinical outcome was assessed, and adverse reactions were recorded.
Results: There was a significant difference in overall response rate between the treatment group and the control group
［96.67% （29/30） vs 70.00% （21/30）, P < 0.05］. Both groups had significant changes in SCORAD score, VAS
score, DLQI score, and the levels of IgE, Th1, Th2, and Th1/Th2 ratio after treatment, and there were significant differences
in these indicators between the two groups after treatment （P < 0.05）. Conclusion: Baidi lotion shows a marked clinical
effect in the treatment of AD with damp-heat accumulation in the skin and can effectively reduce SCORAD score, VAS
score, DLQI score, and the level of IgE, significantly improve the quality of life of patients, inhibit the inflammatory response
of AD, and rapidly control itching, possibly by regulating Th1/Th2 imbalance. |
| Key words: atopic dermatitis damp-heat accumulation in the skin Baidi lotion potassium permanganate desloratadine
citrate disodium |
