| 摘要: |
| 目的：观察化痰平喘合剂治疗慢性阻塞性肺疾病急性加重期（acute exacerbation of chronic obstructive pulmonary disease，AECOPD）痰热壅肺证的临床疗效。方法：选取80例AECOPD痰热壅肺证患者，将其随机分为治疗组和对照组，对照组采用西医常规治疗，治疗组在对照组基础上加用化痰平喘合剂，2组均以7 d为1个疗程，共治疗2个疗程。观察2组咳嗽咳痰缓解时间、抗生素使用时间、慢性阻塞性肺炎患者自我评估测试问卷（COPD Assessment Test，CAT）评分、中医证候评分、动脉血气分析指标水平、安全性指标，并评价临床疗效。结果：总有效率治疗组为92.11%（35/38），对照组为79.49%（31/39），2组比较，差异有统计学意义（P<0.05）；2组咳嗽咳痰缓解时间、抗生素使用时间比较，治疗组均优于对照组（P<0.05）；2组CAT 评分、中医证候评分、动脉血气分析指标水平治疗前后组内比较及治疗后组间比较，差异均有统计学意义（P<0.05）；不良事件发生率治疗组为 5.26%（2/38），对照组为7.69%（3/39），2组比较，差异无统计学意义（P>0.05）。结论：化痰平喘合剂联合常规西医治疗 AECOPD 痰热壅肺证，能显著改善患者临床症状、肺通气功能及缺氧状态， 减少咳嗽咳痰缓解时间和抗生素使用时间，疗效确切，安全性良好，值得临床推广应用。 |
| 关键词: 慢性阻塞性肺疾病 急性加重期 痰热壅肺证 化痰平喘合剂 临床疗效 |
| DOI： |
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| Clinical effect of Huatan Pingchuan mixture in treatment of acute exacerbation of chronic obstructive pulmonary disease with phlegm-heat obstructing the lung: An analysis of 38 cases |
| ZOU Qing,HUANG Xinhua,ZOU Juanlan,YI Qiuxiang,LYU Sha |
| (Hengyang Hospital of Traditional Chinese Medicine, Hengyang 421200, Hunan, China) |
| Abstract: |
| Objective: To investigate the clinical effect of Huatan Pingchuan mixture in the treatment of acute exacerbation of chronic obstructive pulmonary disease （AECOPD） with phlegm-heat obstructing the lung. Methods: A total of 80 AECOPD patients with phlegm-heat obstructing the lung were randomly divided into treatment group and control group. The patients in the control group received conventional Western medicine treatment, and those in the treatment group received Huatan Pingchuan mixture in addition to the treatment in the control group. Each course of treatment was 7 days, and both groups were treated for 2 courses. The two groups were observed in terms of the time to relief of cough and expectoration, duration of antibiotic use, COPD assessment test （CAT） score, traditional Chinese medicine （TCM） syndrome score, arterial blood gas parameters, and safety indicators, and clinical outcome was assessed. Results: There was a significant difference in overall response rate between the treatment group and the control group ［92.11% （35/38） vs 79.49% （31/39）, P < 0.05］. Compared with the control group, the treatment group had significantly better results of time to relief of cough and expectoration and duration of antibiotic use （P < 0.05）. After treatment, both groups had significant changes in CAT score, TCM syndrome score, and arterial blood gas parameters, and there were significant differences in these indicators between the two groups after treatment （P < 0.05）. There was no significant difference in the incidence rate of adverse reactions between the treatment group and the control group ［5.26%（2/38） vs 7.69% （3/39）, P > 0.05］. Conclusion: In the treatment of AECOPD with phlegm-heat obstructing the lung, Huatan Pingchuan mixture can significantly improve clinical symptoms, pulmonary ventilation function, and anoxia and shorten the time to relief of cough and expectoration and the duration of antibiotic use, with a marked clinical effect and a favorable safety profile. |
| Key words: chronic obstructive pulmonary disease acute exacerbation phlegm-heat obstructing the lung Huatan Pingchuan mixture clinical effect |
