| 摘要: |
| 目的：基于脑-肠轴理论采用隔面碗药灸脐法联合八卦揉腹干预心脾两虚型失眠的临床疗效。方法：选取120例心脾两虚型失眠患者，将其随机分为西药组、灸脐组、联合组，每组各40例。西药组采用艾司唑仑治疗，灸脐组采用隔面碗药灸脐法治疗，联合组采用隔面碗药灸脐法联合八卦揉腹治疗，比较3组匹兹堡睡眠质量指数（Pittsburgh Sleep Quality Index，PSQI）评分，肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）、白细胞介素-6（interleukin-6，IL-6）、白细胞介素-1β（interleukin-1β，IL-1β）、5 - 羟色胺（5-hydroxytryptamine，5-HT）、去甲肾上腺素（norepinephrine，NE）、γ-氨基丁酸（γ-aminobutyric acid，GABA）水平，并评价临床疗效。结果：总有效率西药组为87.5%（35/40），灸脐组为60.0%（24/40），联合组为85.0%（34/40），3组比较，差异有统计学意义（P<0.05）；PSQI各项评分干预前后组内比较，差异均有统计学意义（P<0.05）；催眠药物使用方面，灸脐组、联合组与西药组干预后比较，差异有统计学意义（P<0.05），而灸脐组与联合组比较，差异无统计学意义（P>0.05）；其余评分方面，西药组、联合组与灸脐组比较，差异均有统计学意义（P<0.05），而西药组与联合组比较，差异无统计学意义（P>0.05）；3组TNF-α、IL-6、IL-1β、5-HT、NE、GABA水平干预前后组内比较，差异有统计学意义（P<0.05），且西药组、联合组与灸脐组干预后比较，差异有统计学意义（P<0.05），而西药组与联合组干预后比较，差异无统计学意义（P>0.05）。结论：隔面碗药灸脐法联合八卦揉腹可有效改善心脾两虚型失眠患者的症状，改善患者体内炎症因子和神经递质的水平，且治疗效果与口服艾司唑仑效果相当。 |
| 关键词: 失眠 心脾两虚型 脑-肠轴 中西医结合疗法 脐灸 八卦揉腹 艾司唑仑 |
| DOI： |
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| Clinical effect of medicated umbilical moxibustion with a bowl made of wheat flour combined with Bagua abdominal massage in treatment of insomnia with heart-spleen deficiency syndrome based on the brain-gut axis theory: An analysis of 40 cases |
| LIANG Jianing,PENG Xiaoyu,LIU Jingwen,WU Qinjing,HE Shuyan |
| (Hunan University of Chinese Medicine, Changsha 410208, Hunan, China;Hunan Academy of Chinese Medicine, Changsha,410013, Hunan, China;Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Changsha 410006, Hunan, China) |
| Abstract: |
| Objective: To investigate the clinical effect of medicated umbilical moxibustion with a bowl made of wheat flour combined with Bagua abdominal massage in the treatment of insomnia with heart-spleen deficiency syndrome based on the brain-gut axis theory. Methods: A total of 120 insomnia patients with heart-spleen deficiency syndrome were enrolled and randomly divided into Western medicine group, umbilical moxibustion group, and combination group, with 40 patients in each group. The patients in the Western medicine group received estazolam, those in the umbilical moxibustion group received medicated umbilical moxibustion with a bowl made of wheat flour, and those in the combination group received medicated umbilical moxibustion with a bowl made of wheat flour combined with Bagua abdominal massage. The three groups were compared in terms of Pittsburgh Sleep Quality Index （PSQI） score, tumor necrosis factor-α （TNF-α）, interleukin-6 （IL-6）, interleukin-1β （IL-1β）, 5-hydroxytryptamine （5-HT）, norepinephrine （NE）, and γ-aminobutyric acid （GABA）, and clinical outcome was assessed. Results: The overall response rate was 87.5% （35/40） in the Western medicine group, 60.0% （24/40） in the umbilical moxibustion group, and 85.0% （34/40） in the combination group, with a significant difference between the three groups （P < 0.05）. All groups had significant changes in PSQI scores after intervention （P < 0.05）; there was a significant difference in the use of hypnotic drugs between the umbilical moxibustion group and the Western medicine group and between the combination group and the Western medicine group （P < 0.05）, while there was no significant difference between the umbilical moxibustion group and the combination group （P > 0.05）; there were significant differences in the other scores between the Western medicine group and the umbilical moxibustion group and between the combination group and the umbilical moxibustion group （P < 0.05）, while there were no significant differences between the Western medicine group and the combination group（P > 0.05）. All three groups had significant changes in the levels of TNF-α, IL-6, IL-1β, 5-HT, NE, and GABA after intervention, with significant differences between the Western medicine group and the umbilical moxibustion group and between the combination group and the umbilical moxibustion group （P < 0.05）, while there were no significant differences between the Western medicine group and the combination group after intervention （P > 0.05）. Conclusion: For insomnia patients with heart-spleen deficiency syndrome, medicated umbilical moxibustion with a bowl made of wheat flour combined with Bagua abdominal massage can effectively alleviate symptoms and improve the levels of inflammatory factors and neurotransmitters, with a comparable clinical effect to oral administration of estazolam. |
| Key words: insomnia heart-spleen deficiency syndrome brain-gut axis integrated traditional Chinese and Western medicine therapy umbilical moxibustion Bagua abdominal massage estazolam |
