| 摘要: |
| 目的：观察清解化攻汤联合调脂口服液治疗高甘油三酯血症性急性胰腺炎的临床疗效。方法：将60例轻度/中度重症高甘油三酯血症性急性胰腺炎患者随机分为治疗组和对照组，每组各 30例。对照组采用西医常规治疗，治疗组在对照组基础上联合口服或鼻饲清解化攻汤和调脂口服液治疗，2组疗程均为 7 d。比较2组治疗第1天、第3天、第7天血清炎症相关指标［白细胞（white blood cell，WBC）、C-反应蛋白（C-reactive protein，CRP）、肿瘤坏死因子-α（tumore necrosis factor-α，TNF-α）、白细胞介素-6（interleukin-6，IL-6）］水平、血脂和胰腺炎相关指标［甘油三酯（triglyceride, TG）、总胆固醇（total cholesterol，TC）、淀粉酶（amylase，AMY）、D-二聚体］水平，记录2组并发症的发生率和总住院费用，比较临床疗效。结果：总有效率治疗组为90.00%（27/30），对照组为73.33%（22/30），2组比较，差异无统计学意义（P>0.05）；2组治疗第3天、第7天血清炎症相关指标、血脂和胰腺炎相关指标均较本组前一时间节点下降（P<0.05）；治疗组治疗第3天、第7天各指标均低于对照组，但仅CRP、TNF-α、IL-6、TG、TC、D-二聚体差异有统计学意义（P<0.05）。2组并发症发生率、总住院费用比较，差异均无统计学意义（P>0.05）。结论：清解化攻汤联合调脂口服液治疗高甘油三酯血症性急性胰腺炎，能更好地减轻患者炎症反应，促进脂质代谢，改善微循环，促进病情恢复。 |
| 关键词: 高甘油三酯血症性急性胰腺炎 清解化攻汤 调脂口服液 临床研究 |
| DOI： |
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| Clinical effect of Qingjie Huagong decoction combined with lipid-regulating oral liquid in treatment of hypertriglyceridemic acute pancreatitis: An analysis of 30 cases |
| KANG Yi,XUAN Chuanfeng,LOU Yu,LIAO Jin,AN Xiaoxia,SU Pan,LING Xiaodan |
| (The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530001, Guangxi, China) |
| Abstract: |
| Objective: To investigate the clinical effect of Qingjie Huagong decoction combined with lipid-regulating oral liquid in the treatment of hypertriglyceridemic acute pancreatitis. Methods: A total of 60 patients with mild/moderate-severe hypertriglyceridemic acute pancreatitis were randomly divided into treatment group and control group, with 30 patients in each group. The patients in the control group received conventional Western medicine treatment, while those in the treatment group received oral administration or nasogastric feeding of Qingjie Huagong decoction and lipid-regulating oral liquid in addition to the treatment in the control group, and the course of treatment was 7 days for both groups. The two groups were compared in terms of serum inflammatory markers （white blood cell count, C-reactive protein, tumor necrosis factor-α, and interleukin-6）and the serum levels of blood lipids and pancreatitis-related indicators （triglyceride, total cholesterol, amylase, and D-dimer）on days 1, 3, and 7 of treatment, as well as the incidence rate of complications and total hospital costs, and clinical outcome was also compared between the two groups. Results: There was no significant difference in overall response rate between the treatment group and the control group ［90.00% （27/30） vs 73.33% （22/30）, P>0.05］. Both groups had significant reductions in serum inflammatory markers and the serum levels of blood lipids and pancreatitis-related indicators on days 3 and 7 of treatment（P<0.05）, and the treatment group had lower levels of these indicators than the control group on days 3 and 7 of treatment, but with significant differences in C-reactive protein, tumor necrosis factor-α, interleukin-6, triglyceride, total cholesterol, and D-dimer（P<0.05）. There were no significant differences in the incidence rate of complications and total hospital costs between the two groups（P>0.05）. Conclusion: In the treatment of hypertriglyceridemic acute pancreatitis, Qingjie Huagong decoction combined with lipid-regulating oral liquid can alleviate inflammatory response, enhance lipid metabolism, improve microcirculation, and promote disease recovery. |
| Key words: hypertriglyceridemic acute pancreatitis Qingjie Huagong decoction lipid-regulating oral liquid clinical study |
