| 摘要: |
| 目的：观察降脂通络软胶囊对非酒精性脂肪性肝病（non-alcoholic fatty liver disease，NAFLD）患者肝脏脂肪含量的影响及其临床疗效。方法：选取NAFLD患者100例，将其随机分为治疗组和对照组，每组各50例。对照组予以双环醇片治疗，治疗组在对照组基础上予以降脂通络软胶囊治疗，2组均治疗12周。比较2组肝功能指标、血脂指标、肝脏脂肪含量及肝纤维化指标、生存质量评分，并评价临床疗效。结果：总有效率治疗组为92.00%（46/50）高于对照组的76.00%（38/50），2组比较，差异有统计学意义（P＜0.05）。2组肝功能指标、血脂指标、肝脏脂肪含量及肝纤维化指标、生存质量评分治疗前后组内比较及治疗后组间比较，差异均有统计学意义（P＜0.05）。结论：降脂通络软胶囊对NAFLD患者肝脏脂肪含量及代谢指标有改善作用，有良好的临床疗效，能够改善肝功能及血脂指标，降低患者肝脏脂肪含量，改善肝脏纤维化，提升患者生存质量。 |
| 关键词: 非酒精性脂肪性肝病 降脂通络软胶囊 肝脏脂肪含量 肝功能指标 血脂指标 |
| DOI： |
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| Effect of Jiangzhi Tongluo soft capsules on liver fat content and its clinical effect in treatment of nonalcoholic fatty liver disease |
| ZHANG Baojing,WANG Shujun,XU Xia |
| (The First Peoples Hospital of Zhengzhou，Zhengzhou 451100，Henan，China) |
| Abstract: |
| Objective：To investigate the effect of Jiangzhi Tongluo soft capsules on liver fat content and its clinical effect in patients with nonalcoholic fatty liver disease (NAFLD).Methods：A total of 100 patients with NAFLD were enrolled and randomly divided into treatment group and control group，with 50 patients in each group.The patients in the control group were given bicyclol tablets，while those in the treatment group were given Jiangzhi Tongluo soft capsules in addition to the treatment in the control group;the course of treatment was 12 week for both groups.The two groups were compared in terms of liver function parameters，blood lipid parameters，liver fat content，liver fibrosis markers，and quality of life score，and clinical outcome was assessed for both groups.Results：The treatment group had a significantly higher overall response rate than the control group ［92.00% (46/50) vs 76.00% (38/50)，P < 0.05］.After treatment，both groups had significant changes in liver function parameters，blood lipid parameters，liver fat content，liver fibrosis markers，and quality of life score，and there were significant differences in these indicators between the two groups after treatment (P < 0.05).Conclusion：Jiangzhi Tongluo soft capsules can improve liver fat content and metabolic markers in patients with NAFLD，and it has a good clinical effect and can improve liver function and blood lipid parameters，reduce liver fat content，alleviate liver fibrosis，and enhance the quality of life of patients. |
| Key words: nonalcoholic fatty liver disease Jiangzhi Tongluo soft capsule liver fat content liver function parameters blood lipid parameters |
