| 摘要: |
| 目的：应用超声联合血清脑肠肽胃动素（MTL）、血管活性肠肽（VIP）评估脾失健运证和脾胃气虚证厌食症患儿的胃动力差异。方法：将63例厌食症患儿作为研究对象，其中脾失健运证34例，脾胃气虚证29例，另选取健康体检儿童志愿者20例作为健康对照组。采用ELISA法检测分析3组受试者空腹血清MTL、VIP的表达水平，予服液体营养餐200 mL后，超声观察并记算受试者胃窦收缩幅度（ACA），胃窦收缩频率（ACF），胃窦运动指数（MI），饮后30 min、60 min胃排空率，胃半排空时间。结果：与健康对照组比较，2组厌食症患儿MTL、ACA、ACF、MI及饮后30 min、60 min胃排空率低于健康对照组，而VIP高于健康对照组，胃半排空时间长于健康对照组，差异均有统计学意义（P＜0.05）。2组厌食症患儿比较，脾失健运证组MTL、ACA、MI及饮后30 min、60 min胃排空率高于脾胃气虚证组，VIP低于脾胃气虚证组，胃半排空时间短于脾胃气虚证组，差异均有统计学意义（P＜0.05），2组ACF差异无统计学意义（P＞0.05）。结论：超声联合血清MTL、VIP检查能够有效反映厌食症患儿胃动力情况，该检查方法对厌食症患儿的胃动力诊疗效果评估具有重要临床指导意义。 |
| 关键词: 厌食症 脾失健运证 脾胃气虚证 胃动力 超声 脑肠肽胃动素 血管活性肠肽 |
| DOI： |
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| Value of ultrasound combined with serum MTL and VIP in assessing the difference in gastric motility between children with anorexia with dysfunction of the spleen in transportation and those with deficiency of spleen Qi and stomach Qi |
| SHI Yuxia,YANG Hui,RUAN Meijiang |
| (The Second People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine，Fuzhou 350003，Fujian，China) |
| Abstract: |
| Objective：To investigate the value of ultrasound combined with serum motilin (MTL) and vasoactive intestinal peptide (VIP) in assessing the difference in gastric motility between children with anorexia with dysfunction of the spleen in transportation and those with deficiency of spleen Qi and stomach Qi.Methods：A total of 63 children with anorexia were enrolled as subjects，among whom there were 34 children with dysfunction of the spleen in transportation and 29 children with deficiency of spleen Qi and stomach Qi，and 20 children undergoing physical examination were enrolled as healthy control group.ELISA was used to measure the serum levels of MTL and VIP in a fasting state for all three groups，and after administration of 200-mL liquid nutrition meal，ultrasound was used to measure antral contraction amplitude (ACA)，antral contraction frequency (ACF)，motility index (MI)，gastric emptying rate at 30 and 60 minutes after drinking，and gastric emptying half-time.Results：Compared with the healthy control group，the two groups of children with anorexia had significantly lower MTL，ACA，ACF，MI，and gastric emptying rate at 30 and 60 minutes after drinking，a significantly higher level of VIP，and a significantly longer gastric emptying half-time (P＜0.05).Compared with the group with deficiency of spleen Qi and stomach Qi，the group with dysfunction of the spleen in transportation had significantly higher MTL，ACA，MI，and gastric emptying rate at 30 and 60 minutes after drinking，a significantly lower level of VIP，and a significantly shorter gastric emptying half-time (P＜0.05)，while there was no significant difference in ACF between the two groups (P＞0.05).Conclusion：Ultrasound combined with serum MTL and VIP can effectively reflect gastric motility in children with anorexia and thus has an important clinical significance in assessing the treatment outcome of gastric motility in children with anorexia. |
| Key words: anorexia dysfunction of the spleen in transportation deficiency of spleen Qi and stomach Qi gastric motility ultrasound motilin vasoactive intestinal peptide |
