| 摘要: |
| 目的：利用古今医案云平台V2.3.7对自身免疫性甲状腺炎（AIT）非甲亢期的中药方剂进行数据挖掘，探索其用药规律和特点。方法：检索中国知网（CNKI）、维普中文科技期刊数据库（VIP）、万方数据（WANFANG DATA）、PubMed数据库，收集2014年1月1日至2024年2月29日采用中医药治疗AIT非甲亢期的文献，筛选文献并提取中药方剂，对方剂的药物频次、四气五味、关联规则、层次聚类等进行分析。结果：本研究纳入中医治疗AIT非甲亢期药方共 284个，单味药数量为268味，总使用频次3 195次。药物使用频次排名前10位的分别为夏枯草、柴胡、黄芪、白术、茯苓、白芍、浙贝母、当归、甘草、党参。药物四气以温性为首，后依次为平、寒、微寒，五味以甘、苦、辛为主，多归肝、脾经。药物功效以疏肝解郁为主。药物层次聚类获得4类，关联规则显示夏枯草-黄芪是最常用的药对。结论：中医药治疗AIT非甲亢期，既强调疏解肝气、补益脾肾，又重视散结消瘿，并根据病理因素如气滞、痰浊、瘀血采用行气、燥湿、活血等药物。 |
| 关键词: 自身免疫性甲状腺炎非甲亢期 用药规律 数据挖掘 |
| DOI： |
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| Medication rule in treatment of autoimmune thyroiditis in the non-hyperthyroidism stage：A study based on data mining |
| LIN Ziyu,CHEN Wei |
| (Liaoning University of Traditional Chinese Medicine，Shenyang 110847，Liaoning，China;The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110034，Liaoning，China) |
| Abstract: |
| Objective：To investigate the medication rule in the treatment of autoimmune thyroiditis (AIT) in the non-hyperthyroidism stage by performing data mining of traditional Chinese medicine (TCM) prescriptions using Cloud Platform of Ancient and Modern Medical Records V2.3.7.Methods：CNKI，VIP，Wanfang Data，and PubMed were searched for articles on TCM treatment of AIT in the non-hyperthyroidism stage published from January 1，2014 to February 29，2024.The articles were screened，and the TCM prescriptions were extracted and analyzed in terms of drug frequency，four properties and five tastes，association rule，and hierarchical clustering.Results：A total of 284 TCM prescriptions for the treatment of AIT in the non-hyperthyroidism stage were included in this study，involving 268 single herbs，with a total frequency of use of 3 195.The top 10 drugs in terms of frequency of use were Prunella vulgaris，Bupleurum chinense，Astragalus membranaceus，Atractylodes macrocephala Koidz.，Poria cocos，Radix Paeoniae Alba，Fritillaria thunbergii，Angelica sinensis，Radix Glycyrrhizae，and Codonopsis pilosula.Most drugs had a warm nature，followed by those with a neutral，cold or slightly cold nature，and most drugs had a sweet，biter or pungent taste，mainly entering the liver and spleen meridians.Most drugs had the function of soothing the liver and resolving stagnation.Hierarchical clustering obtained 4 clusters，and the association rule analysis showed that Prunella vulgaris-Astragalus membranaceus was the most commonly used drug combination.Conclusion：In the treatment of AIT in the non-hyperthyroidism stage，TCM emphasizes soothing the liver，invigorating spleen and kidney，resolving static blood，and eliminating goiter and applies the drugs for moving Qi，drying dampness，and activating blood based on the pathological factors such as Qi stagnation，phlegm turbidity，and blood stasis. |
| Key words: autoimmune thyroiditis in the non-hyperthyroidism stage medication rule data mining |
