| 摘要: |
| 目的：探讨芪玉降糖膏治疗气阴两虚、脉络瘀阻型早期糖尿病性下肢动脉粥样硬化性病变（LEAD）的临床疗效。方法：将124 例气阴两虚、脉络瘀阻型早期糖尿病性LEAD患者根据随机数字表法分为治疗组和对照组，每组各62 例。对照组给予西医常规治疗，治疗组在对照组基础上加服芪玉降糖膏治疗，治疗12周后比较2组综合疗效、中医证候总积分、总胆固醇（TC）、低密度脂蛋白（LDL-C）、空腹血糖（FBG）、糖化血红蛋白（HbA1c）及踝肱指数（ABI）。结果：总有效率治疗组为95.16%（59/62），高于对照组的80.64%（50/62），差异有统计学意义（P＜0.05）。2组治疗后中医证候总积分、TC、LDL-C、FBG、HbA1c水平均较治疗前下降，ABI较治疗前上升，且治疗组下降及上升幅度均大于对照组，差异均有统计学意义（P＜0.05）。结论：芪玉降糖膏联合西药治疗气阴两虚、脉络瘀阻型早期糖尿病性LEAD疗效颇佳，值得临床推广和应用。 |
| 关键词: 糖尿病 下肢动脉粥样硬化性病变 气阴两虚、脉络瘀阻型 芪玉降糖膏 |
| DOI： |
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| Clinical effect of Qiyu Jiangtang ointment in prevention and treatment of early-stage diabetic lower extremity atherosclerotic disease：An analysis of 62 cases |
| BI Xiaoli,LIU Qing |
| (Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine，Guangzhou 510800，Guangdong，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Qiyu Jiangtang ointment in the prevention and treatment of early-stage diabetic lower extremity atherosclerotic disease (LEAD) with deficiency of both Qi and Yin and obstruction of collaterals.Methods：A total of 124 patients with early-stage diabetic LEAD with deficiency of both Qi and Yin and obstruction of collaterals were divided into treatment group and control group using a random number table，with 62 patients in each group.The patients in the control group received conventional Western medicine treatment，and those in the treatment group received Qiyu Jiangtang ointment in addition to the treatment in the control group.After 12 weeks of treatment，the two groups were compared in terms of overall response，total traditional Chinese medicine (TCM) syndrome score，total cholesterol (TC)，low-density lipoprotein (LDL-C)，fasting blood glucose (FBG)，HbAlc，and ankle-brachial index (ABI).Results：The treatment group had a significantly higher overall response rate than the control group ［95.16% (59/62) vs 80.64% (50/62)，P＜0.05］.After treatment，both groups had significant reductions in total TCM syndrome score，TC，LDL-C，FBG，and HbAlc and a significant increase in ABI，and the treatment group had significantly greater changes than the control group (P＜0.05).Conclusion：Qiyu Jiangtang ointment has a marked clinical effect in the prevention and treatment of early-stage diabetic LEAD with deficiency of both Qi and Yin and obstruction of collaterals and thus holds promise for clinical application. |
| Key words: diabetes lower extremity atherosclerotic disease deficiency of both Qi and Yin and obstruction of collaterals Qiyu Jiangtang ointment |
