| 摘要: |
| 目的：通过数据挖掘探讨严光俊教授治疗肠癌的组方规律和有效方剂，采用网络药理学分析其核心药物的潜在作用机制。方法：收集 2022年1月1日至2022年12月31日严教授治疗肠癌的有效处方，运用SPSS Modeler18.0筛选挖掘其用药规律，运用网络药理学分析核心药物的潜在作用机制。结果：纳入 100首中药方剂，涉及141味中药，药物归经以肝、脾经为主，性味以温寒、甘苦居多，茯苓、白术、白花蛇舌草、黄芪、白英、党参、熟地黄为其核心药物。核心药物主要通过调控细胞凋亡、信号传导、细胞增殖等生物过程，调节磷脂酰肌醇-3-激酶/丝苏氨酸蛋白激酶（PI3K/AKT）信号通路、表皮生长因子受体（EGFR）酪氨酸抑制剂耐药、晚期糖基化终产物-晚期糖基化终末产物受体（AGE-RAGE）信号通路、蛋白聚糖等通路发挥作用。结论：严教授治疗肠癌以“通痞消积”为基本治则，从肝脾论治，以健脾益气为主，理气疏肝为辅，兼顾养血益肾，并针对“瘀”“痰”“湿”“寒”“毒”等兼证灵活加减用药。其核心药物通过多成分、多靶点、多通路的作用机制对肠癌发挥治疗作用。 |
| 关键词: 肠癌 严光俊 数据挖掘 网络药理学 作用机制 |
| DOI： |
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| Medication rule and mechanism of action of Yan Guangjun in treatment of intestinal cancer：A study based on data mining and network pharmacology |
| XIANG Caiqiong,XU Dazhi,WANG Yan |
| (Jingzhou Hospital of Traditional Chinese Medicine，Jingzhou 434000，Hubei，China) |
| Abstract: |
| Objective：To investigate the prescription rule and effective prescriptions of Professor Yan Guangjun in the treatment of intestinal cancer based on data mining，as well as the potential mechanism of action of core drugs based on network pharmacology. Methods：Effective prescriptions were collected from the cases of intestinal cancer treated by Professor Yan from January 1 to December 31，2022. SPSS Modeler 18.0 was used to analyze the medication rule of Professor Yan，and network pharmacology was used to investigate the potential mechanism of action of core drugs. Results：A total of 100 prescriptions were included，involving 141 traditional Chinese medicine drugs. Most drugs entered the liver and spleen meridians，and they mainly had a warm or cold nature and a sweet or bitter taste.The core drugs were Poria cocos，Atractylodes macrocephala Koidz.，Hedyotis diffusa，Astragalus membranaceus，Solanum lyratum Thunb.，Codonopsis pilosula，and prepared Radix Rehmanniae.These core drugs exerted a therapeutic effect by regulating the PI3K/Akt signaling pathway，EGFR tyrosine kinase inhibitor resistance，and the AGE-RAGE signaling pathway via the biological processes including cell apoptosis，signal transduction，and cell proliferation. Conclusion：Professor Yan applies the basic principle of treatment of “clearing up distention and eliminating food retention” and performs treatment from the liver and spleen，with the main methods of strengthening the spleen and benefiting Qi and the assistance of regulating Qi and soothing the liver. Professor Yan also considers the method of nourishing the blood and nourishing the kidney and applies drugs based on the syndromes of stasis，phlegm，dampness，cold，and toxin.The core drugs exert a therapeutic effect on intestinal cancer through multiple components，targets，and pathways. |
| Key words: intestinal cancer Yan Guangjun data mining network pharmacology mechanism of action |
