| 摘要: |
| 目的：观察芪术石斛养胃方治疗气虚血瘀型慢性萎缩性胃炎（CAG）的临床疗效。方法：将70例气虚血瘀型CAG患者随机分为治疗组和对照组，每组各35例。治疗组采用芪术石斛养胃方治疗，对照组采用胃复春片治疗，2组均治疗6个月。观察2组的综合疗效，中医证候评分（胃脘刺痛、纳呆少食、反酸、身倦乏力、大便稀溏），胃蛋白酶原［胃蛋白酶原Ⅰ（PGⅠ）、胃蛋白酶原Ⅱ（PGⅡ）、PGⅠ/PGⅡ］指标，胃泌素（G-17）水平及不良反应发生情况。结果：总有效率治疗组为88.57%（31/35），对照组为54.29%（19/35），2组比较，差异有统计学意义(P<0.01)。治疗组各项中医证候评分、胃蛋白酶原各项指标、G-17水平治疗前后组内比较及治疗后与对照组比较，差异均有统计学意义（P<0.01 或 P<0.05）；而对照组仅中医证候中胃脘刺痛、纳呆少食、大便稀溏评分及PGⅠ水平治疗前后组内比较，差异有统计学意义（P<0.05）。不良反应总发生率治疗组为11.43%（4/35），对照组为22.86%（8/35），2组比较，差异有统计学意义(P<0.05)。结论：芪术石斛养胃方能有效改善气虚血瘀型CAG患者的症状，调节胃肠激素水平，值得临床推广应用。 |
| 关键词: 慢性萎缩性胃炎 气虚血瘀型 中医药疗法 芪术石斛养胃方 |
| DOI： |
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| Clinical effect of Qizhu Shihu Yangwei prescription in treatment of chronic atrophic gastritis with Qi deficiency and blood stasis: An analysis of 35 cases |
| SHI Xiaoling,LI Wenlong,LIU Pengcheng |
| (Municipal Hospital of Traditional Chinese Medicine/Changsha Eighth Hospital，Changsha 410002，Hunan，China) |
| Abstract: |
| Objective: To investigate the clinical effect of Qizhu Shihu Yangwei prescription in the treatment of chronic atrophic gastritis (CAG) with Qi deficiency and blood stasis.Methods: A total of 70 CAG patients with Qi deficiency and blood stasis were randomly divided into treatment group and control group，with 35 patients in each group.The patients in the treatment group received Qizhu Shihu Yangwei prescription，while those in the control group received Weifuchun Tablet，and the course of treatment was 6 months for both groups.The two groups were observed in terms of overall response，traditional Chinese medicine (TCM) syndrome scores (pricking pain in gastric cavity，poor appetite，acid reflux，weakness，and loose stool)，pepsinogens (pepsinogen I (PGI)，pepsinogen II (PGII)，and PGI/PGII ratio)，gastrin-17 (G-17)，and adverse reactions.Results: There was a significant difference in overall response rate between the treatment group and the control group ［88.57% (31/35) vs 54.29% (19/35)，P<0.01］.After treatment，the treatment group had significant changes in TCM syndrome scores，pepsinogens，and G-17，and there were significant differences in these indicators between the two groups after treatment (P<0.01 or P<0.05)，while the control group had significant changes in the TCM syndrome scores of pricking pain in gastric cavity，poor appetite，and loose stool and the level of PGI (P<0.05).There was a significant difference in the incidence rate of adverse events between the treatment group and the control group ［11.43% (4/35) vs 22.86% (8/35)，P<0.05］.Conclusion: For CAG patients with Qi deficiency and blood stasis，Qizhu Shihu Yangwei prescription can effectively improve their symptoms and regulate the levels of gastrointestinal hormones，and therefore，it holds promise for clinical application. |
| Key words: chronic atrophic gastritis Qi deficiency and blood stasis traditional Chinese medicine treatment Qizhu Shihu Yangwei prescription |
