| 摘要: |
| 目的：运用中医传承计算平台（V3.0）分析中医药治疗肺癌伴恶性胸腔积液的用药规律。方法：计算机检索2000年1月1日至2022年2月28日中国知网（CNKI）、万方数据（WANFANG DATA）、维普中文科技期刊数据库（VIP）中关于中药复方治疗肺癌伴恶性胸腔积液的文献,分析中药的性味归经、功效、频次、药物组合、关联规则及聚类等。结果：共纳入文献98篇,处方103首,中药197味。频次≥20次的中药有18味,排前10位的依次为葶苈子、茯苓、白术、黄芪、大枣、甘草、泽泻、桂枝、半夏、薏苡仁。四气以寒、温、平为主;五味以甘、苦、辛为主;归经以肺、脾、胃经为主。排前3位的功效依次为补虚、利水渗湿、化痰止咳平喘。用药频次≥20次的中药组合有37组,排前4位的依次为茯苓-葶苈子、白术-茯苓、茯苓-黄芪、大枣-葶苈子。支持度≥25%的核心药物为黄芪、白术、茯苓、甘草、葶苈子、大枣、桂枝、泽泻。中药聚类分析提取到4个核心组合。结论：肺癌伴恶性胸腔积液多属晚期,以气血阴阳俱虚为本,饮停胸胁为标,病机多虚实夹杂。中医药治疗此病多以甘温益气补虚治本,苦寒泻肺利水治标,同时兼以温阳化气。 |
| 关键词: 肺癌 恶性胸腔积液 中医药疗法 数据挖掘 用药规律 |
| DOI： |
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| Medication rule of compound traditional Chinese medicine prescriptions in treatment of lung cancer with malignant pleural effusion：An analysis based on data mining |
| GUAN Peng,SHEN Yunbo,LIU Feng |
| (The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China) |
| Abstract: |
| Objective：To investigate the medication rule of traditional Chinese medicine (TCM) in the treatment of lung cancer with malignant pleural effusion using Traditional Chinese Medicine Inheritance Computing System (V3.0).Methods：CNKI,Wanfang Data,and VIP were searched for articles on compound TCM prescriptions in the treatment of lung cancer with malignant pleural effusion published from January 1,2000 to February 28,2022,and the TCM drugs were analyzed in terms of taste,flavor,meridian entry,function,frequency,and drug combination.Association rule analysis and cluster analysis were also performed.Results：A total of 98 articles were included,involving 103 prescriptions and 197 TCM drugs.There were 18 TCM drugs with a frequency of ≥20,with the top 10 drugs of pepperweed seed,Poria cocos,Atractylodes macrocephala Koidz.,Astragalus membranaceus,jujube,Radix Glycyrrhizae,Alisma orientalis,Ramulus Cinnamomi,Pinellia ternata,and coix seed.Most TCM drugs were cold,warm or neutral in nature,had a sweet,bitter,or pungent taste,and entered the lung,spleen,and stomach meridians.The top three functions were tonifying deficiency,promoting diuresis and draining dampness,and resolving phlegm and relieving cough and asthma.There were 37 TCM drug combinations with a frequency of ≥20,with the top four combinations of Poria cocos-pepperweed seed,Atractylodes macrocephala Koidz.-Poria cocos,Poria cocos-Astragalus membranaceus,and jujube-pepperweed seed.The core drugs with a support degree of ≥25% were Astragalus membranaceus,Atractylodes macrocephala Koidz.,Poria cocos,Radix Glycyrrhizae,pepperweed seed,jujube,Ramulus Cinnamomi,and Alisma orientalis.The cluster analysis of TCM drugs obtained four core drug combinations.Conclusion：Lung cancer with malignant pleural effusion is often in the advanced stage,with Qi-blood Yin-Yang deficiency as the root cause and fluid retention in chest and hypochondrium as the manifestation,and its pathogenesis is mixed with deficiency and excess.In the TCM treatment of this disease,Qi-tonifying and deficiency-tonifying therapy with sweet and warm-natured drugs is used for radical treatment,and lung-purging and diuresis-inducing therapy with bitter and cold-natured drugs is used for symptomatic treatment,with the combination of Yang-warming and Qi-transforming therapy. |
| Key words: lung cancer malignant pleural effusion traditional Chinese medicine treatment data mining medication rule |
