| 摘要: |
| 目的：观察肺痨康对慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）模型大鼠脏器系数的影响，探究其对COPD模型大鼠是否具有治疗作用及其作用机制。方法：将60只SD雄性大鼠适应性喂养1周后随机分为空白组、模型组、地米塞松组及肺痨康高、中、低剂量组，采用香烟烟熏（CS）+脂多糖（LPS）气管内滴注复合因素法建立COPD大鼠模型，于造模第15天开始，肺痨康低、中、高剂量组分别予肺痨康药液0.1405、0.281、0.843ml/（kg·d）灌胃，地塞米松组予地塞米松每天每只0.054mg灌胃，空白组、模型组予相应体积0.9%氯化钠注射液灌胃，每天1次。灌胃14d后处死、取材、称重并计算相关脏器系数。结果：与模型组比较，地塞米松组、肺痨康高剂量组能不同程度地降低肺脏系数（P<0.01），提高脾脏系数和胸腺系数（P<0.01，P<0.05），肺痨康中、低剂量组能提高胸腺系数（P<0.01）。结论：肺痨康高剂量可减轻模型大鼠肺脏的炎症反应并增强其免疫力。 |
| 关键词: COPD 肺痨康 脏器系数 实验研究 |
| DOI： |
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| Effect of Feilaokang on organ coefficient in rats with chronic obstructive pulmonary disease |
| WANG Dongmei,WANG Li,JIA Huilin |
| (Chengdu University of Traditional Chinese Medicine，Chengdu 610075，Sichuan，China) |
| Abstract: |
| Objective：To investigate the effect of Feilaokang on organ coefficient in rats with chronic obstructive pulmonary disease（COPD），as well as its therapeutic effect on COPD and possible mechanism of action.Methods：After one week of adaptive feeding，60 Sprague-Dawley rats were randomly divided into blank group，model group，dexamethasone group，and high-，middle-，and low-dose Feilaokang groups.A rat model of COPD was established by cigarette smoke combined with intratracheal instillation of lipopolysaccharide.From day 15 of modeling，the rats in the low-，middle-，and high-dose Feilaokang groups were given Feilaokang drug solution once a day by gavage at a dose of 0.1405，0.281，and 0.843 ml/kg/d，respectively，each rat in the dexamethasone group was given dexamethasone once a day by gavage at a dose of 0.054mg/d，and those in the blank group and the model group were given an equal volume of 0.9% sodium chloride injection once a day by gavage.The rats were sacrificed after 14 days of treatment by gavage，and related samples were collected and weighed to calculate the organ coefficient.Results：Compared with the model group，the dexamethasone group and the high-dose Feilaokang group had a significant reduction in lung coefficient（P<0.01）and significant increases in spleen coefficient and thymus index（P<0.01 or P<0.05），and the middle-and low-dose Feilaokang groups had a significant increase in thymus index（P<0.01）.Conclusion：High-dose Feilaokang can alleviate lung inflammatory response and enhance immunity in rats with COPD. |
| Key words: chronic obstructive pulmonary disease Feilaokang organ coefficient experimental study |
