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| 基于数据挖掘分析仇湘中治疗腰椎间盘突出症的用药规律 |
| 唐继能,刘永鑫,张缘,罗聪,仇湘中,郭玉星 |
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| (湖南中医药大学,湖南 长沙,410208;湖南省中西医结合医院,湖南 长沙,410006;湖南中医药大学,湖南 长沙,410208;湖南中医药大学第一附属医院,湖南 长沙,410007) |
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| 摘要: |
| 目的：运用数据挖掘方法分析仇湘中教授治疗腰椎间盘突出症（lumbar disc herniation，LDH）的用药规律。方法：收集2022年1月1日至2025年6月30日仇湘中教授门诊诊断为LDH的医案，通过古今医案云平台V3.0，对中药频次及功效、性味归经进行统计分析，采用关联规则、复杂网络分析和聚类算法挖掘核心药物组合及药对。结果：共纳入1 335份有效处方，涉及248味中药，累计频次26 309次，前5位高频药物为黄芪、丹参、萆薢、独活、党参。中药功效以强筋骨、补肝肾、利水消肿、祛风湿、祛风止痛为主；中药属性方面：四气以温、平、微温为主，五味以甘、苦、辛为主，多归肝、脾、肾经。关联规则分析结果共得到20对高频关联药物，复杂网络分析筛选出14味核心药物，聚类分析结果共得到3组核心组合。结论：仇湘中教授认为LDH以“肝虚络痹”为核心病机，多虚多瘀，应从肝论治、标本兼治。其用药特点以温平为主、甘苦辛为核心，兼顾药性制衡、个体差异与辨证加减。 |
| 关键词: 腰椎间盘突出症 数据挖掘 用药规律 肝虚络痹 仇湘中 |
| DOI： |
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| Medication rule of Qiu Xiangzhong in treatment of lumbar disc herniation: A study based on data mining |
| TANG Jineng,LIU Yongxin,ZHANG Yuan,LUO Cong,QIU Xiangzhong,GUO Yuxing |
| (Hunan University of Chinese Medicine, Changsha 410208, Hunan, China; Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Changsha 410006, Hunan, China;Hunan University of Chinese Medicine, Changsha 410208, Hunan, China; The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan, China) |
| Abstract: |
| Objective: To investigate the medication rule of Professor Qiu Xiangzhong in the treatment of lumbar disc herniation （LDH） based on data mining. Methods: Medical records were collected from the patients who were diagnosed with LDH at the outpatient service of Professor Qiu Xiangzhong from January 1, 2022 to June 30, 2025. Based on Cloud Platform of Ancient and Modern Medical Records V3.0, a statistical analysis was performed for the frequency, function, nature, taste, and meridian entry of traditional Chinese medicine （TCM） drugs, and the association rule analysis, the complex network analysis, and clustering algorithms were used to explore core drug combinations and pairs. Results: A total of 1 335 valid prescriptions were included, involving 248 TCM drugs, with a cumulative frequency of 26 309, and the top five drugs in terms of frequency were Astragalus membranaceus, Salvia miltiorrhiza, Dioscoreae Spongiosae Rhizoma, Angelica pubescens, and Codonopsis pilosula. The main functions of the TCM drugs included strengthening tendons and bones, tonifying the liver and kidney, promoting diuresis to reduce edema, expelling wind-damp, and dispelling pathogenic wind to relieve pain. The drugs mainly had a warm, neutral or slightly warm nature and a sweet, bitter or pungent taste, and they mainly entered the liver, spleen, and kidney meridians. The association rule analysis obtained 20 pairs of high-frequency drugs, the complex network analysis identified 14 core TCM drugs, and the cluster analysis obtained 3 core combinations. Conclusion: Professor Qiu Xiangzhong believes “liver deficiency and collateral obstruction” is the core pathogenesis of LDH, characterized by deficiency and stasis. Therefore, the treatment of LDH should focus on the principles of treatment from the liver and treating both manifestation and root cause of disease. Professor Qiu Xiangzhong mainly used drugs with a warm or neutral nature and a sweet, bitter or pungent taste, while giving considerations to the balance of medicinal properties, individual differences, and syndrome differentiation-based modifications. |
| Key words: lumbar disc herniation data mining medication rules liver deficiency and collateral obstruction Qiu Xiangzhong |
