| 摘要: |
| 目的：观察补气通络方加减治疗气虚血瘀型结直肠癌奥沙利铂化疗所致外周神经毒性(chemotherapy-induced peripheral neuropathy，CIPN）患者的临床疗效。方法：选取气虚血瘀型结直肠癌奥沙利铂CIPN患者70例，将其随机分为治疗组和对照组，每组各35例，对照组予以甲钴胺常规治疗，治疗组在对照组基础上联合补气通络方加减治疗，观察2组患者治疗前后CIPN 20评分、卡氏功能状态 (Karnofsky Performance Status，KPS)评分、疼痛评分（Numerical Rating Scale，NRS）和血液毒性反应发生率及分级情况。结果：2组患者CIPN 20评分、KPS评分、NRS评分治疗前后组内比较及治疗后组间比较，差异均有统计学意义（P＜0.05）;治疗后，治疗组在血液毒性反应发生率及分级情况方面，白细胞计数、血红蛋白、血小板计数的改善均优于对照组（P＜0.05）。结论：补气通络方加减能延缓气虚血瘀型奥沙利铂CIPN的发展进程，减缓手足麻木、疼痛等症状，改善患者生活质量。 |
| 关键词: 结直肠癌 奥沙利铂 外周神经毒性 气虚血瘀型 补气通络方加减 |
| DOI： |
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| Clinical effect of modified Buqi Tongluo prescription in prevention and treatment of oxaliplatin chemotherapy-induced peripheral neurotoxicity in colorectal cancer with Qi deficiency and blood stasis：An analysis of 35 cases |
| LIN Fangfeng,WANG Wenwu,LIN Mengyan |
| (The Third Peoples Hospital Affiliated to Fujian University of Traditional Chinese Medicine，Fuzhou 350108，Fujian，China) |
| Abstract: |
| Objective：To investigate the clinical effect of modified Buqi Tongluo prescription in the prevention and treatment of oxaliplatin chemotherapy-induced peripheral neurotoxicity (CIPN) in colorectal cancer with Qi deficiency and blood stasis.Methods：A total of 70 patients with colorectal cancer with Qi deficiency and blood stasis who experienced oxaliplatin CIPN were enrolled and randomly divided into treatment group and control group，with 35 patients in each group.The patients in the control group were given conventional medicine treatment with mecobalamin，and those in the treatment group were given modified Buqi Tongluo prescription in addition to the treatment in the control group.The two groups were observed in terms of CIPN 20 score，Karnofsky Performance Scale (KPS) score，and numerical rating scale (NRS) score before and after treatment，as well as the incidence rate and grade of hematotoxicity reaction.Results：After treatment，both groups had significant changes in CIPN 20，KPS，and NRS scores，and there were significant differences in these scores between the two groups after treatment (P < 0.05).Compared with the control group after treatment，the treatment group had significantly better results of the incidence rate and grade of hematotoxicity reaction，as well as significantly better improvements in leukocyte count，hemoglobin，and platelet count (P < 0.05).Conclusion：Modified Buqi Tongluo prescription can delay the progression of oxaliplatin CIPN in colorectal cancer with Qi deficiency and blood stasis，alleviate the symptoms of numbness and pain in hands and feet，and improve the quality of life of patients. |
| Key words: colorectal cancer oxaliplatin peripheral neurotoxicity Qi deficiency and blood stasis modified Buqi Tongluo prescription |
