| 摘要: |
| 目的：观察中医综合疗法治疗肝郁化火型部分性性早熟女童的临床疗效及安全性。方法：将66 例部分性性早熟女童按随机分配原则和是否接受中医治疗分为治疗组30 例（脱落3 例）和对照组30 例（剔除3 例）。对照组予以健康生活方式干预，治疗组在健康生活方式干预的基础上，加用丹栀逍遥散加减联合耳穴压豆治疗，2组均治疗12周。观察2组治疗前、治疗后、随访时（治疗结束后12周）的Tanner分期、促卵泡激素（follicle-stimulating hormone，FSH)和促黄体素（luteinzing hormone，LH)水平、子宫长度、卵巢容积、骨龄、身高，并观察不良反应发生情况。结果：治疗后、随访时治疗组的乳房Tanner分期优于对照组（P＜0.05），血清FSH、LH水平均低于对照组（P＜0.05），双侧卵巢容积均小于对照组（P＜0.05），但子宫长度与对照组比较，差异无统计学意义（P＞0.05）。随访结果显示，治疗组骨龄小于对照组（P＜0.05），但身高与对照组比较，差异无统计学意义（P＞0.05）。治疗过程中，治疗组有2 例患儿口服中药后出现轻微腹泻，2 d后自行恢复，其他患儿未发现相关不良反应。结论：中医综合疗法可以有效抑制肝郁化火型部分性性早熟女童第二性征发育。 |
| 关键词: 部分性性早熟 女童 中医综合疗法 肝郁化火 |
| DOI： |
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| Clinical effect of integrated traditional Chinese medicine therapy in treatment of girls with partial precocious puberty with liver depression transforming into fire |
| FENG Mengjun,PENG Nanzhi,DING Ke |
| (Xiangtan Maternal and Child Health Hospital，Xiangtan 411100，Hunan，China) |
| Abstract: |
| Objective：To investigate the clinical effect and safety of integrated traditional Chinese medicine (TCM) therapy in the treatment of girls with partial precocious puberty with liver depression transforming into fire.Methods：A total of 66 girls with partial precocious puberty with liver depression transforming into fire were enrolled，and based on the principle of randomization and according to whether they were willing to receive TCM therapy，they were divided into treatment group with 30 girls (3 were lost to follow-up) and control group with 30 girls (3 were excluded).The girls in the control group received healthy lifestyle intervention，while those in the treatment group received modified Danzhi Xiaoyao powder combined with ear acupoint bean pressing in addition to the treatment in the control group，and the course of treatment was 12 weeks for both groups.The two groups were observed in terms of Tanner stage，the levels of follicle-stimulating hormone (FSH) and luteinzing hormone (LH)，length of uterus，ovarian volume，bone age，and body height before treatment，after treatment，and at the time of follow-up (at 12 weeks after treatment)，and the incidence rates of adverse reactions were also observed.Results：Compared with the control group after treatment and at the time of follow-up，the treatment group had a significantly better breast Tanner stage (P＜0.05)，significantly lower serum levels of FSH and LH (P＜0.05)，and a significantly lower volume of both ovaries (P＜0.05)，while there was no significant difference in the length of uterus between the two groups (P＞0.05).Follow-up results showed that the treatment group had a significantly lower bone age than the control group (P＜0.05)，while there was no significant difference in body height between the two groups (P＞0.05).During the treatment course，two pediatric patients in the treatment group experienced mild diarrhea after oral administration of the Chinese herbal medicine，which resolved spontaneously within two days without additional treatment. No related adverse reactions were observed in other patients.Conclusion：Integrated TCM therapy can effectively inhibit the development of secondary sexual characteristics in girls with partial precocious puberty with liver depression transforming into fire. |
| Key words: partial precocious puberty girls integrated traditional Chinese medicine therapy liver depression transforming into fire |
