| 摘要: |
| 目的：基于R语言分析绍派伤寒治疗温病的用药规律。方法：收集《绍派伤寒名家验案精选》中治疗温病的中医药处方，运用R语言对处方用药进行频次、性味归经、相关性及关联规则、聚类分析。结果：共纳入医案处方111首，涉及中药212味。获得高频药物28味，其中排名前3位的药物依次为连翘、生地黄、甘草；药物功效以清热、解表、化痰止咳平喘为主，药物性味以甘寒、苦寒为主，多归肺经、胃经、心经。选取用药频次>5次的中药进行相关性分析，得到相关系数较高的排名前3位的药对组合为附子-生姜、通草-佩兰、通草-赤茯苓；关联分析共获得核心药对组合23个，包含16味中药；聚类分析得到5类。结论：绍派伤寒治疗温病以清热祛邪、解表化痰、补益扶正为主。 |
| 关键词: 绍派伤寒 温病 《绍派伤寒名家验案精选》 用药规律 数据挖掘 用药频次 聚类分析 |
| DOI： |
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| Medication rule of experts of the Shaoxing School in typhoid studies in treatment of febrile disease：A study based on data mining |
| GU Jiayin,ZHAO Jialu |
| (Zhejiang Chinese Medical University，Hangzhou 310053，Zhejiang，China) |
| Abstract: |
| Objective：To investigate the medication rule of the experts of the Shaoxing School in typhoid studies in the treatment of febrile disease based on R language.Methods：Traditional Chinese medicine （TCM）prescriptions for the treatment of febrile disease were collected from A Selection of Proven Cases by Experts of the Shaoxing School in Typhoid Studies，and R language was used to perform frequency，taste/nature/meridian entry，correlation，association rule，and cluster analyses for TCM drugs in prescriptions.Results：A total of 111 prescriptions were included，involving 212 TCM drugs.A total of 28 high-frequency drugs were obtained，among which the top 3 drugs were Forsythia suspensa，Radix Rehmanniae，and Radix Glycyrrhizae.Drug functions mainly included clearing heat，relieving exterior syndrome，resolving phlegm，and relieving cough and asthma.Most drugs had a sweet-cold or bitter-cold taste and mainly entered the lung，stomach，and heart meridians.A correlation analysis was performed for TCM drugs with a frequency of use of >5 times，and the results showed that the top 3 drug combinations in terms of correlation coefficient were Radix Aconiti Lateralis Preparata-ginger，Tetrapanax papyriferus-Herba Eupatorii，and Tetrapanax papyriferus-Rubra Poria.The association rule analysis obtained 23 core drug combinations，involving 16 TCM drugs，and the cluster analysis obtained 5 clusters.Conclusion：The experts of the Shaoxing School in typhoid studies mainly applied the methods of clearing heat and eliminating pathogen，relieving exterior syndrome and resolving phlegm，and tonifying and strengthening vital Qi in the treatment of febrile disease. |
| Key words: experts of the Shaoxing School in typhoid studies febrile disease A Selection of Proven Cases by Experts of the Shaoxing School in Typhoid Studies medication rule data mining frequency of use of drugs cluster analysis |
