| 摘要: |
| 目的：探讨中西医结合疗法对老年头颈部肿瘤患者放疗后医院感染发生的影响。方法：选取84例老年头颈部肿瘤放疗后患者作为研究对象，按照随机数字表法将其分为治疗组和对照组，每组各42例。对照组予基础预防方案，治疗组在此基础上配合使用中西医结合干预措施。通过对比2组干预后的感染率、住院时间、不同标本（呼吸系统、伤口、消化系统、泌尿系统的分泌物）的阳性率、主要病原菌（肺炎克雷伯菌、白色假丝酵母菌、流感嗜血杆菌、金黄色葡萄球菌、鲍曼不动杆菌、铜绿假单胞菌）分离度、感染后抗生素使用时间进行疗效评价。结果：医院感染率治疗组为16.67%（7/42），低于对照组的35.71%（15/42），差异有统计学意义（P＜0.05）；治疗组住院时间、抗生素使用时间均短于对照组，呼吸道、伤口分泌物的阳性率及肺炎克雷伯菌、金黄色葡萄球菌、鲍曼不动杆菌分离度均低于对照组（P＜0.05）。结论：中西医结合疗法可以降低老年头颈部肿瘤患者放疗后医院感染发生率，缩短住院时间。 |
| 关键词: 头颈部肿瘤 老年 医院感染 放疗 抗生素 五味消毒饮 沙参麦冬汤 |
| DOI： |
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| Effect of integrated traditional Chinese and Western medicine therapy on nosocomial infection after radiotherapy in elderly patients with head and neck cancer |
| YANG Lijiang,LI Yang,JIANG Xinyu |
| (Hunan University of Chinese Medicine，Changsha 410208，Hunan，China;Hunan Cancer Hospital，Changsha 410013，Hunan，China) |
| Abstract: |
| Objective：To investigate the effect of integrated traditional Chinese and Western medicine therapy on nosocomial infection after radiotherapy in elderly patients with head and neck cancer.Methods：A total of 84 elderly patients with head and neck cancer who underwent radiotherapy were enrolled as subjects，and they were divided into treatment group and control group using a random number table，with 42 patients in each group.The patients in the control group were given the basic prevention regimen，and those in the treatment group were given integrated traditional Chinese and Western medicine therapy in addition to the treatment in the control group.The two groups were compared in terms of infection rate after intervention，the length of hospital stay，the positive rate of different specimens (secretions from the respiratory tract，wound，the digestive tract，and the urinary system)，the degree of isolation of main pathogenic bacteria (Klebsiella pneumoniae，Candida albicans，Haemophilus influenzae，Staphylococcus aureus，Acinetobacter baumannii，and Pseudomonas aeruginosa)，and the time of antibiotic use after infection，and treatment outcome was assessed.Results：The treatment group had a significantly lower nosocomial infection rate than the control group ［16.67% (7/42) vs 35.71% (15/42)，P＜0.05］.Compared with the control group，the treatment group had significantly shorter length of hospital stay and time of antibiotic use，significantly lower positive rates of secretions from the respiratory tract and wound，and a significantly lower degree of isolation of Klebsiella pneumoniae，Staphylococcus aureus，and Acinetobacter baumannii (P＜0.05).Conclusion：Integrated traditional Chinese and Western medicine therapy can reduce the incidence rate of nosocomial infection after radiotherapy，and the length of hospital stay in elderly patients with head and neck cancer. |
| Key words: head and neck cancer elderly nosocomial infection radiotherapy antibiotics Wuwei Xiaodu decoction Shashen Maidong decoction |
