| 摘要: |
| 目的：探讨芎芪化瘀止痛汤加减治疗气虚血瘀型紧张型头痛（TTH）的临床效果。方法：选取100 例气虚血瘀型TTH患者，按随机数字表法分为治疗组和对照组，每组各50 例。对照组口服普瑞巴林胶囊治疗，治疗组在对照组基础上加用芎芪化瘀止痛汤加减治疗，疗程均为4周。比较2组临床疗效、头痛发作情况、中医症状积分、脑血流动力学、生活质量及不良反应。结果：总有效率治疗组为96.00%（48/50），对照组为82.00%（41/50），2组比较，差异有统计学意义（P＜0.05）；治疗后，与对照组比较，治疗组头痛发作次数减少，每次头痛持续时间缩短，疼痛程度降低，中医症状积分减少，大脑中动脉（MCA）、后动脉（PCA）、前动脉（ACA）血流速度降低，生活质量评分升高，差异均有统计学意义（P＜0.01）；不良反应发生率治疗组为4.00%（2/50），对照组为8.00%（4/50），2组比较，差异无统计学意义（P>0.05）。结论：芎芪化瘀止痛汤加减可提高气虚血瘀型TTH患者临床疗效，纠正脑血流动力学异常状态，减少头痛发作，改善生活质量，且安全可靠。 |
| 关键词: 紧张型头痛 气虚血瘀型 芎芪化瘀止痛汤加减 普瑞巴林胶囊 |
| DOI： |
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| Clinical effect of modified Xiongqi Huayu Zhitong decoction in treatment of tension-type headache with Qi deficiency and blood stasis：An analysis of 50 cases |
| ZHU Zhengkai,WANG Nian,LI Fang |
| (Department of Encephalopathy，Taizhou Hospital of Traditional Chinese Medicine，Taizhou 225300，Jiangsu，China) |
| Abstract: |
| Objective：To investigate the clinical effect of modified Xiongqi Huayu Zhitong decoction in the treatment of tension-type headache (TTH) with Qi deficiency and blood stasis. Methods：A total of 100 TTH patients with Qi deficiency and blood stasis were divided into treatment group and control group using a random number table，with 50 patients in each group.The patients in the control group received oral administration of pregabalin capsules，while those in the treatment group received modified Xiongqi Huayu Zhitong decoction in addition to the treatment in the control group，and the course of treatment was 4 weeks for both groups.The two groups were compared in terms of clinical outcome，headache attacks，traditional Chinese medicine (TCM) symptom score，cerebral hemodynamics，quality of life，and adverse events. Results：There was a significant difference in overall response rate between the treatment group and the control group ［96.00% (48/50) vs 82.00% (41/50)，P<0.05］.Compared with the control group after treatment，the treatment group had significant reductions in the number of headache attacks，the duration of each headache attack，the degree of pain，TCM syndrome score，and blood flow velocities of the middle cerebral artery，the posterior cerebral artery，and the anterior cerebral artery，as well as a significant increase in quality of life score (P<0.01).There was no significant difference in the incidence rate of adverse events between the treatment group and the control group ［4.00% (2/50) vs 8.00% (4/50)，P>0.05］.Conclusion：For TTH patients with Qi deficiency and blood stasis，modified Xiongqi Huayu Zhitong decoction can improve clinical outcome，correct abnormal cerebral hemodynamics，reduce headache attacks，and improve quality of life，and it is safe and reliable. |
| Key words: tension-type headache Qi deficiency and blood stasis modified Xiongqi Huayu Zhitong decoction pregabalin capsules |
