| 摘要: |
| 目的：观察益气温阳方治疗气血亏虚兼阳虚型慢性荨麻疹(CU)的临床疗效及其对血清25羟基维生素D（25HVD）水平的影响。方法：将87 例气血亏虚兼阳虚型CU患者随机分为治疗组（45 例）和对照组（42 例），另选取30名健康成人为正常组。对照组给予氯雷他定片、盐酸西替利嗪片口服治疗，治疗组在对照组基础上配合益气温阳方治疗，2组疗程均为30 d。于治疗前后对2组临床症状进行评分、测定血清25HVD水平，记录不良反应发生情况，评定综合疗效。结果：综合疗效总有效率治疗组为86.67%（39/45），对照组为73.81%（31/42），2组比较，差异有统计学意义（P＜0.05)。2组临床症状评分治疗前后组内比较及治疗后组间比较，差异均有统计学意义（P＜0.05)。治疗前2组患者与正常组血清25HVD水平比较，差异均有统计学意义（P＜0.05)；治疗后，治疗组血清25HVD水平升高，且高于对照组，差异均有统计学意义（P＜0.05)，治疗组和对照组血清25HVD水平均低于正常组，差异有统计学意义（P＜0.05)。结论：益气温阳方治疗气血亏虚兼阳虚型CU疗效确切，能上调患者血清25HVD水平，可能是其作用机制之一。 |
| 关键词: 慢性荨麻疹 气血亏虚兼阳虚型 益气温阳方 25HVD |
| DOI： |
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| Clinical effect of Yiqi Wenyang prescription in treatment of chronic urticaria and its effect on serum 25-hydroxyvitamin D |
| WANG Jianxuan,CHU Kaiyu,LUO Wenfeng |
| (Foshan Hospital of Traditional Chinese Medicine，Foshan 528000，Guangdong，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Yiqi Wenyang prescription in the treatment of chronic urticarial (CU) with deficiency of Qi and blood and Yang deficiency and its effect on the serum level of 25-hydroxyvitamin D (25HVD).Methods：A total of 87 CU patients with deficiency of Qi and blood and Yang deficiency were randomly divided into treatment group with 45 patients and control group with 42 patients，and 30 healthy adults were enrolled as normal group.The patients in the control group received oral administration of loratadine tablets and cetirizine hydrochloride tablets，while those in the treatment group received Yiqi Wenyang prescription in addition to the treatment in the control group，and the course of treatment was 30 days for both groups.Clinical symptom score and serum 25HVD level were measured before and after treatment，adverse reactions were recorded，and overall response was evaluated.Results：There was a significant difference in overall response rate between the treatment group and the control group ［86.67% (39/45) vs 73.81% (31/42)，P＜0.05］.Both groups had a significant change in clinical symptom score after treatment，with a significant difference between the two groups after treatment (P＜0.05）.Before treatment，there was a significant difference in serum 25HVD level between the two groups and the normal group (P＜0.05)；after treatment，the treatment group had a significant increase in serum 25HVD level，with a significantly higher level than the control group (P＜0.05)，and both the treatment group and the control group had a significantly lower serum 25HVD level than the normal group (P＜0.05）.Conclusion：Yiqi Wenyang prescription has a marked clinical effect in the treatment of CU with deficiency of Qi and blood and Yang deficiency，possibly by upregulating the serum level of 25HVD. |
| Key words: chronic urticarial deficiency of Qi and blood and Yang deficiency Yiqi Wenyang prescription 25-hydroxyvitamin D |
