| 摘要: |
| 目的：挖掘史伟教授治疗IgA肾病的用药规律，为中医治疗IgA肾病提供新思路。方法：回顾性收集史教授治疗IgA肾病的处方，筛选并建立IgA肾病方剂数据库，运用中医传承辅助平台(V2.5)软件挖掘其用药规律。结果：共纳入患者150 例，处方1099首，涉及中药225味。高频用药排名前10位的是茯苓、党参、黄芪、水蛭、白术、淫羊藿、杜仲、芡实、丹参、续断。功效以清热、收敛、利水渗湿为主。药性以温、平为主，药味以甘、苦味居多，多归脾、肝经。出现频率较高的药物组合为党参-茯苓、黄芪-茯苓、党参-黄芪等，演化得到核心组合8条，新处方4首。结论：史教授治疗IgA肾病强调脾肾同调，从脾补肾；标本兼顾，同时兼顾清热利湿；注重活血通络，擅用虫类药物化瘀通络。新处方符合史伟教授用药规律，为IgA肾病的临床治疗或科研提供了新思路。 |
| 关键词: IgA肾病 用药规律 数据挖掘 中医传承辅助平台 史伟 |
| DOI： |
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| Medication rule of Shi Wei in treatment of IgA nephropathy based on Traditional Chinese Medicine Inheritance Support System |
| LAN Fang,ZHANG Dandan,ZHAO Jie |
| (The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，Guangxi，China;Guangxi University of Chinese Medicine，Nanning 530200，Guangxi，China) |
| Abstract: |
| Objective：To investigate the medication rule of Professor Shi Wei in the treatment of IgA nephropathy，and to provide new ideas for traditional Chinese medicine (TCM) treatment of IgA nephropathy.Methods：A retrospective analysis was performed for the prescriptions by Professor Shi in the treatment of IgA nephropathy，which were screened to establish a database of prescriptions for IgA nephropathy，and Traditional Chinese Medicine Inheritance Support System (V2.5) was used to identify the medication rule.Results：A total of 150 patients were enrolled，involving 1099 prescriptions and 225 TCM drugs.The top 10 TCM drugs in terms of frequency of use were Poria cocos，Codonopsis pilosula，Astragalus membranaceus，leech，Atractylodes macrocephala Koidz.，Herba Epimedii，Eucommia ulmoides，Semen Euryales，Salvia miltiorrhiza，and teasel root.The main functions included clearing heat，astringing，promoting diuresis，and draining dampness.Most drugs had a warm or neutral nature and a sweet or bitter taste，and they mainly entered the spleen and liver meridians.The drug combinations with a relatively high frequency included Codonopsis pilosula-Poria cocos，Astragalus membranaceus-Poria cocos，and Codonopsis pilosula-Astragalus membranaceus，and the evolution analysis obtained 8 core combinations and 4 new prescriptions.Conclusion：In the treatment of IgA nephropathy，Professor Shi emphasizes the simultaneous regulation of the spleen and the kidney and tonifying the kidney via the spleen，and he also proposes to address both the symptoms and root causes and consider both heat-clearing and diuresis-promoting therapies.He focuses on activating blood and dredging collaterals and is good at using medicinal insects for resolving stasis and dredging collaterals.New prescriptions are consistent with the medication rule of Professor Shi Wei，which provides new ideas for the clinical treatment of IgA nephropathy or related scientific research. |
| Key words: IgA nephropathy medication rule data mining Traditional Chinese Medicine Inheritance Support System Shi Wei |
