| 摘要: |
| 目的：观察益气活血方治疗糖尿病性心肌病气阴两虚夹瘀证的疗效及其对患者心功能和炎症因子水平的影响。方法：将90 例糖尿病性心肌病气阴两虚夹瘀证患者随机分为2组，每组各45 例。对照组采用西医常规治疗，治疗组在对照组治疗基础上联合益气活血方治疗。比较2组治疗前后血糖及血脂水平、心功能指标、心率变异性指标、炎症因子、中医证候评分、心室重构指标变化，并观察不良反应和评价临床疗效。结果：总有效率治疗组为88.89%（40/45），优于对照组的71.11%（32/45），2组比较，差异有统计学意义（P<0.05）；2组血糖血脂水平、心功能指标、心率变异性指标、炎症因子、中医证候评分、心室重构指标治疗前后组内比较及治疗后组间比较，差异均有统计学意义（P<0.05）；且2组患者治疗期间均未见明显不良反应。结论：益气活血方联合西医常规疗法治疗糖尿病性心肌病气阴两虚夹瘀证疗效显著，能够有效调节血糖、血脂水平，缓解临床症状，改善心功能，且无明显不良反应，其疗效机制可能与抑制炎症反应有关。 |
| 关键词: 糖尿病性心肌病 气阴两虚夹瘀证 中西医结合疗法 益气活血方 心功能 |
| DOI： |
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| Clinical effect of Qi-tonifying and blood-activating prescription in treatment of diabetic cardiomyopathy with deficiency of both Qi and Yin and stasis：An analysis of 45 cases |
| ZHANG Mei,XING Dong |
| (Nanyang Hospital of Traditional Chinese Medicine，Nanyang 473007，Henan，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Qi-tonifying and blood-activating prescription in the treatment of diabetic cardiomyopathy with deficiency of both Qi and Yin and stasis and its effect on cardiac function and inflammatory factors.Methods：A total of 90 patients with diabetic cardiomyopathy with deficiency of both Qi and Yin and stasis were randomly divided into control group and treatment group，with 45 patients in each group.The patients in the control group were given conventional Western medicine treatment，and those in the treatment group were given Qi-tonifying and blood-activating prescription in addition to the treatment in the control group.The two groups were compared in terms of the changes in blood glucose and blood lipid levels，cardiac function parameters，heart rate variability，inflammatory factors，traditional Chinese medicine (TCM) syndrome score，and ventricular remodeling parameters after treatment，and adverse reactions and clinical outcome were observed and assessed.Results：The treatment group had a significantly better overall response rate than the control group ［88.89% (40/45) vs 71.11% (32/45)，P<0.05］.After treatment，both groups had significant changes in blood glucose and blood lipid levels，cardiac function parameters，heart rate variability，inflammatory factors，TCM syndrome score，and ventricular remodeling parameters，and there were significant differences in these indicators between the two groups after treatment (P<0.05).No significant adverse reactions were observed during treatment in either group.Conclusion：Qi-tonifying and blood-activating prescription combined with conventional Western medicine treatment has a marked clinical effect in the treatment of diabetic cardiomyopathy with deficiency of both Qi and Yin and stasis and can effectively regulate blood glucose and blood lipid levels，alleviate clinical symptoms，and improve cardiac function，with little adverse effect，possibly by inhibiting inflammatory response. |
| Key words: diabetic cardiomyopathy deficiency of both Qi and Yin and stasis integrated traditional Chinese and Western medicine therapy Qi-tonifying and blood-activating prescription cardiac function |
