| 摘要: |
| 目的：探讨祛痰化瘀方联合多烯磷脂酰胆碱治疗痰瘀互结型非酒精性脂肪性肝炎的疗效。方法：将痰瘀互结型非酒精性脂肪性肝炎患者80 例随机分为治疗组与对照组，每组各40 例。对照组采用多烯磷脂酰胆碱治疗，治疗组在对照组基础上联合祛痰化瘀方治疗。观察2组的中医证候疗效，肝功能［丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、谷氨酰转肽酶（GGT）、总胆汁酸（TBA）］和血脂［三酰甘油（TC）、总胆固醇（TG）］，受控衰减指数（CAP）及肝脏超声疗效。结果：中医证候疗效总有效率治疗组为82.5%（33/40），对照组为72.5%（29/40），2组比较，差异有统计学意义（P＜0.05）。治疗后2组ALT、AST、GGT、TBA、TC、TG、CAP均较治疗前改善，且治疗组AST、TBA、TC、TG、CAP的改善幅度大于对照组（P＜0.05）。肝脏超声疗效总有效率治疗组为77.5%（31/40），对照组为40.0%（16/40），组间比较，差异有统计学意义（P＜0.05）。结论：祛痰化瘀方联合多烯磷脂酰胆碱治疗痰瘀互结型非酒精性脂肪性肝炎疗效确切，值得临床推广应用。 |
| 关键词: 非酒精性脂肪性肝炎 痰瘀互结证 祛痰化瘀方 多烯磷脂酰胆碱 |
| DOI： |
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| Clinical effect of phlegm-expelling and stasis-resolving prescription combined with polyene phosphatidylcholine in treatment of non-alcoholic steatohepatitis with syndrome of intermingled phlegm and blood stasis：An analysis of 40 cases |
| SHEN Hezheng,LI Helun |
| (Linyi Hospital of Traditional Chinese Medicine，Linyi 276037，Shandong，China) |
| Abstract: |
| Objective：To investigate the clinical effect of phlegm-expelling and stasis-resolving prescription combined with polyene phosphatidylcholine in the treatment of non-alcoholic steatohepatitis with syndrome of intermingled phlegm and blood stasis.Methods：A total of 80 patients with non-alcoholic steatohepatitis with syndrome of intermingled phlegm and blood stasis were randomly divided into treatment group and control group，with 40 patients in each group.The patients in the control group were given polyene phosphatidylcholine，and those in the treatment group were given phlegm-expelling and stasis-resolving prescription in addition to the treatment in the control group.The two groups were observed in terms of the treatment outcome of TCM syndrome，liver function ［alanine aminotransferase (ALT)，aspartate aminotransferase (AST)，gamma-glutamyl transpeptidase (GGT)，and total bile acid (TBA)］，blood lipids ［triglyceride (TC) and total cholesterol (TG)］，controlled attenuation parameter (CAP)，and the treatment outcome of liver ultrasound.Results：There was a significant difference in the overall response rate of TCM syndrome between the treatment group and the control group ［82.5% (33/40) vs 72.5% (29/40)，P＜0.05］.After treatment，both groups had improvements in ALT，AST，GGT，TBA，TC，TG，and CAP，and the treatment group had significantly greater improvements than the control group (P＜0.05).There was a significant difference in the overall response rate of liver ultrasound between the treatment group and the control group ［77.5% (31/40) vs 40.0% (16/40)，P＜0.05］.Conclusion：Phlegm-expelling and stasis-resolving prescription combined with polyene phosphatidylcholine has a marked clinical effect in the treatment of non-alcoholic steatohepatitis with syndrome of intermingled phlegm and blood stasis and thus holds promise for clinical application. |
| Key words: non-alcoholic steatohepatitis syndrome of intermingled phlegm and blood stasis phlegm-expelling and stasis-resolving prescription polyene phosphatidylcholine |
