| 摘要: |
| 目的：基于R语言探析中药灌肠治疗溃疡性结肠炎（UC）的用药规律。方法：检索中国知网（CNKI）、万方数据（WANFANG DATA）、维普中文科技期刊数据库（VIP）、中国生物医学文献服务系统（SinoMed）中有关中药灌肠治疗UC的方药信息，建立“UC中药灌肠治疗方药信息数据库”，使用R语言软件对用药频次、用药关联及药物聚类进行数据挖掘。结果：共得到有效处方1270首，涉及中药220味，总用药频次10032次，使用频次>100次的药物中以清热药最多，止血药、补虚药次之。四气以寒性药为主，五味以苦味药最多。关联规则分析提示白及、黄连、黄柏、地榆、白头翁之间存在较强关联；聚类分析获得3类。结论：UC的灌肠治疗以清热药、止血药为主，核心药物有白及、黄连、黄柏、地榆、白头翁，治疗大法为清热化湿解毒、凉血止血，兼以收敛固涩、健脾益气。 |
| 关键词: 溃疡性结肠炎 中药灌肠 数据挖掘 R语言 |
| DOI： |
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| Medication rule of traditional Chinese medicine enema in treatment of ulcerative colitis：A study based on R language |
| ZHANG Honghai,ZHU Lei,JI Yuejin |
| (The Affiliated Hospital of Nanjing University of Chinese Medicine，Nanjing 210004，Jiangsu，China) |
| Abstract: |
| Objective：To investigate the medication rule of traditional Chinese medicine (TCM) enema in the treatment of ulcerative colitis (UC) based on R language.Methods：CNKI，Wanfang Data，VIP，and SinoMed were searched to obtain the prescriptions and drugs for TCM enema treatment of UC and establish a database of such prescriptions and drugs，and R language software was used to perform data mining from the aspects of drug frequency，medication association，and drug cluster analysis.Results：A total of 1270 valid prescriptions were obtained，involving 220 TCM drugs，and the total drug frequency was 10032.Heat-clearing drugs accounted for the highest proportion among the drugs with a frequency of >100，followed by hemostasis drugs and deficiency-tonifying drugs.Most drugs were warm in nature or had a bitter taste.The association rule analysis showed that there was a relatively strong association between Rhizoma Bletillae，Coptis chinensis，Phellodendri Chinensis Cortex，Sanguisorba officinalis，and Pulsatilla chinensis，and the cluster analysis obtained 3 clusters.Conclusion：Heat-clearing drugs and hemostasis drugs are mainly used for enema treatment of UC，and the core drugs include Rhizoma Bletillae，Coptis chinensis，Phellodendri Chinensis Cortex，Sanguisorba officinalis，and Pulsatilla chinensis.Heat-clearing，dampness-resolving，and detoxicating therapy and blood-cooling and hemostatic therapy are the main treatment methods，with the considerations of astringent therapy and spleen-invigorating and Qi-tonifying therapy. |
| Key words: ulcerative colitis traditional Chinese medicine enema data mining R language |
