| 摘要: |
| 目的：观察通痹颗粒治疗气血亏虚、痰瘀互结型类风湿关节炎（RA）的临床疗效及对氧化应激的影响。方法：将60 例气血亏虚、痰瘀互结型RA患者随机分为治疗组和对照组，每组各30 例。对照组予甲氨蝶呤联合美洛昔康治疗，治疗组在对照组基础上加通痹颗粒治疗，2组疗程均为8周。比较2组综合疗效，中医证候积分，血清学指标［血沉（ESR）、C反应蛋白（CRP）］水平，氧化应激指标［超氧化物歧化酶（SOD）、丙二醛（MDA）］水平及不良反应。结果：总有效率治疗组为83.33%（25/30），对照组为60.00%（18/30），组间比较，差异有统计学意义（P<0.05）；治疗后2组中医证候积分与ESR、CRP、MDA水平均较治疗前降低，SOD水平较治疗前升高，且治疗组改善程度优于对照组（P<0.05或P<0.01）。结论：通痹颗粒可改善气血亏虚、痰瘀互结型RA患者的临床症状、体征、实验室指标，并能调节氧化应激状态，且不良反应少，值得临床推广应用。 |
| 关键词: 类风湿关节炎 气血亏虚、痰瘀互结型 通痹颗粒 氧化应激 |
| DOI： |
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| Clinical effect of Tongbi granules in treatment of rheumatoid arthritis and its effect on oxidative stress |
| LONG Linyu,LIU Yujia,WU Yiying |
| (Hunan University of Chinese Medicine，Changsha 410208，Hunan，China;The First Affiliated Hospital of Hunan University of Chinese Medicine，Changsha 410007，Hunan，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Tongbi granules in the treatment of rheumatoid arthritis (RA) with deficiency of Qi and blood and syndrome of intermingled phlegm and blood stasis and its effect on oxidative stress.Methods：A total of 60 RA patients with deficiency of Qi and blood and syndrome of intermingled phlegm and blood stasis were randomly divided into treatment group and control group，with 30 patients in each group.The patients in the control group were given methotrexate combined with meloxicam，while those in the treatment group were given Tongbi granules in addition to the treatment in the control group，and the course of treatment was 8 weeks for both groups.The two groups were compared in terms of overall response，traditional Chinese medicine (TCM) score，serological markers ［erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)］，oxidative stress indicators ［superoxide dismutase (SOD) and malondialdehyde (MDA)］，and adverse reactions.Results：There was a significant difference in overall response rate between the treatment group and the control group ［83.33% (25/30) vs 60.00% (18/30)，P<0.05］.After treatment，both groups had significant reductions in TCM syndrome score，ESR，CRP，and MDA and a significant increase in SOD，and the treatment group had significantly better improvements than the control group (P<0.05 or P<0.01).Conclusion：For RA patients with deficiency of Qi and blood and syndrome of intermingled phlegm and blood stasis，Tongbi granules can improve their clinical symptoms，signs，and laboratory markers and regulate oxidative stress status with few adverse reactions，and therefore，it holds promise for clinical application. |
| Key words: rheumatoid arthritis deficiency of Qi and blood and syndrome of intermingled phlegm and blood stasis Tongbi granules oxidative stress |
