| 摘要: |
| 目的：运用数据挖掘技术分析理气温阳法治疗脾胃虚寒型胃痛的用药规律。方法：采用回顾性研究方法，收集2016年1月至2020年9月在广西中医药大学第一附属医院扶阳流派工作室门诊医案中脾胃虚寒型胃痛医案121则，提取其方药信息，并基于Microsoft Office Excel 2019和IBM SPSS Statistic 22.0软件建立方-证数据库。采用频次分析、聚类分析、关联规则分析和因子分析等方法，提取核心网络药物及药对，建立理气温阳法治疗脾胃虚寒型胃痛的数学模型。结果：纳入中药方剂199首，涉及中药76味，累计用药频数2677次。高频药物共26味，排前5位的是海螵蛸、砂仁、生姜、厚朴、白蔻仁；药物功效以化湿、理气、补虚为主；药性以温性药为主，其次为寒性药、平性药；药味以辛味药为主，其次为苦味药、甘味药；药物归经主要归脾、肺、胃经。聚类分析提取到2个药物组合；关联规则分析得到2味中药药对14对，3味中药药组3组，其中生姜、桂枝尖与其他药物关联性最高。结论：扶阳流派辨治脾胃虚寒型胃痛，临证常以扶正补虚为本，温通中上焦为要，如温阳佐以理气，或燥湿化痰以温阳行气，或理气和中以温阳止痛，或纳气补虚以温阳化阴。 |
| 关键词: 胃痛 脾胃虚寒型 理气温阳 用药规律 |
| DOI： |
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| Medication rule of the Qi-regulating and Yang-warming therapy for the treatment of stomachache with deficient cold of spleen and stomach based on data mining techniques |
| PANG Tingting,LI Chunlin,FAN Shan |
| (Guangxi University of Chinese Medicine，Guangxi 530001，Nanning，China) |
| Abstract: |
| Objective：To investigate the medication rule of the Qi-regulating and Yang-warming therapy for the treatment of stomachache with deficient cold of spleen and stomach.Methods：A retrospective analysis was performed for the 121 medical records of stomachache with deficient cold of spleen and stomach selected from the outpatient medical records of The First Affiliated Hospital of Guangxi University of Chinese Medicine Fuyang School Workshop from January 2016 to September 2020，and Microsoft Office Excel 2019 and IBM SPSS Statistic 22.0 were used to establish a prescription-syndrome database.The methods including frequency analysis，cluster analysis，association rule analysis，and factor analysis were used to extract the core network drugs and drug combinations and establish a mathematic model for the Qi-regulating and Yang-warming therapy for stomachache with deficient cold of spleen and stomach.Results：A total of 199 traditional Chinese medicine (TCM) prescriptions were included and involved 76 TCM drugs，with a cumulative medication frequency of 2677 times.There were 26 high-frequency TCM drugs，and the top 5 drugs were cuttlebone，Amomum villosum，ginger，Magnolia officinalis，and Amomum cardamomum.The efficacy of the drug is mainly to eliminate dampness, regulate qi, and tonify deficiency.The drugs with warm nature accounted for the highest proportion，followed by those with cold or mild nature；the drugs with pungent flavor accounted for the highest proportion，followed by those with bitter or sweet flavor；as for meridian entry，most drugs entered the spleen，lung，and stomach meridians.The cluster analysis obtained 2 drug combinations；the association rule analysis obtained 14 drug combinations (each containing 2 TCM drugs) and 3 drug combinations (each containing 3 TCM drugs)，among which ginger and Ramulus Cinnamomi showed the strongest association with other drugs.Conclusion：In the syndrome differentiation-based treatment of stomachache with deficient cold of spleen and stomach，Fuyang School focuses on strengthening vital Qi，tonifying deficiency，and especially warming the upper Jiao and the middle Jiao in clinical practice，such as the Yang-warming and Qi-regulating therapy，the dampness-drying and phlegm-eliminating therapy to warm Yang and move Qi，regulating Qi and harmonizing the middle Jiao to warm Yang and relieve pain，or the Qi-absorption and deficiency-tonifying therapy to warm Yang and activate Yin. |
| Key words: stomachache deficient cold of spleen and stomach Qi-regulating and Yang-warming therapy medication rule |
