| 摘要: |
| 目的：观察启膈化瘀汤治疗中晚期食管癌痰瘀互结证的疗效及其对肿瘤标志物与免疫指标的影响。方法：选取46 例中晚期食管癌痰瘀互结证患者纳入本研究,给予启膈化瘀汤治疗3个月后,观察患者中医证候疗效、治疗前后中医证候积分、血清肿瘤标志物及免疫指标的水平。结果：治疗后中医证候疗效总有效率为91.30%（42/46）;主要临床证候（吞咽困难、呕吐痰涎、消瘦乏力、胸背疼痛、声音嘶哑）积分较治疗前降低,差异有统计学意义（P<0.05）;癌胚抗原（CEA）、鳞状上皮癌相关抗原（SCC）较治疗前明显降低,差异有统计学意义（P<0.05）;血清免疫球蛋白（IgM、IgG、IgA）较治疗前明显升高,差异有统计学意义（P<0.05）。结论：启膈化瘀汤可改善患者的临床症状,提高机体免疫功能,抑制肿瘤生长,提高患者生活质量,值得临床进一步推广应用。 |
| 关键词: 中晚期食管癌 痰瘀互结型 启膈化瘀汤 |
| DOI： |
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| Clinical effect of Qige Huayu decoction in treatment of advanced esophageal cancer and its effects on tumor markers and immune parameters |
| XU Yapei,YANG Qian,YANG Jing |
| (Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang 050011,Hebei,China) |
| Abstract: |
| Objective：To investigate the clinical effect of Qige Huayu decoction in the treatment of advanced esophageal cancer with intermingled phlegm and blood stasis and its effects on tumor markers and immune parameters.Methods：A total of 46 patients with advanced esophageal cancer with intermingled phlegm and blood stasis were enrolled and treated with Qige Huayu decoction for 3 months,and the patients were observed in terms of treatment outcome of traditional Chinese medicine (TCM) syndrome,TCM syndrome scores before and after treatment,serum tumor markers,and immune parameters.Results：After treatment,the overall response rate of TCM syndrome was 91.30% (42/46),and there were significant reductions in the scores of main clinical syndromes (dysphagia,vomiting of phlegm-drool,emaciation and weakness,chest and back pain,and hoarseness) (P<0.05).After treatment,there were significant reductions in carcinoembryonic antigen and squamous cell carcinoma antigen (P<0.05) and significant increases in serum immunoglobulins (IgM,IgG,and IgA) (P<0.05).Conclusion：Qige Huayu decoction can improve patients’ clinical symptoms and immune function,inhibit tumor growth,and improve quality of life,and therefore,it holds promise for clinical application. |
| Key words: advanced esophageal cancer intermingled phlegm and blood stasis Qige Huayu decoction |
