| 摘要: |
| 目的：观察经肝动脉灌注中药榄香烯乳栓塞治疗原发性肝癌肝郁脾虚、瘀毒内结证的临床疗效和安全性。方法：将60 例原发性肝癌患者随机分为治疗组和对照组,每组各30 例。治疗组采用中药榄香烯经肝动脉灌注栓塞术治疗,对照组采用化疗药物经肝动脉灌注栓塞术治疗。观察2组患者中医临床证候积分、生活质量评分、瘤体客观疗效、毒副作用发生情况及1年生存情况。结果：治疗组在改善中医临床证候、提高生活质量方面优于对照组,组间差异均有统计学意义（P<0.01,P＜0.05）;但在瘤体客观疗效方面与对照组相当,组间差异无统计学意义（P＞0.05）。2组治疗后毒副作用情况比较,治疗组血红蛋白（HGB）、血小板（PLT）、谷氨酸氨基转移酶（ALT）、碱性磷酸酶（AKP）4个指标均优于对照组,差异均有统计学意义（均P＜0.01）;2组治疗后血液、消化、泌尿系统各指标毒副作用分级情况比较,除HGB、TBIL以外,治疗组各指标分级情况均优于对照组（均P＜0.05）。治疗组生存情况略优于对照组,但组间差异无统计学意义（P＞0.05）。结论：采用中药榄香烯经肝动脉灌注栓塞术治疗能明显改善原发性肝癌肝郁脾虚、瘀毒内结证患者的中医临床症状,提高其生活质量,较灌注化疗药物的对照组毒副作用更小,值得进一步研究及推广。 |
| 关键词: 原发性肝癌 介入栓塞术 榄香烯 |
| DOI： |
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| Clinical effect of hepatic arterial infusion of traditional Chinese medicine elemene emulsion in treatment of primary liver cancer：An analysis of 30 cases |
| MA Ronghui,CAI Mei,GUO Yurou |
| (Cancer Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830011,Xinjiang,China;The Affiliated Hospital of Hunan Academy of Chinese Medicine,Changsha 410006,Hunan,China;Hunan University of Chinese Medicine,Changsha 410208,Hunan,China) |
| Abstract: |
| Objective：To investigate the clinical effect and safety of hepatic arterial infusion of traditional Chinese medicine (TCM) elemene emulsion in the embolization treatment of primary liver cancer with stagnation of liver Qi and spleen deficiency and internal accumulation of stasis and toxin.Methods：A total of 60 patients with primary liver cancer were randomly divided into treatment group and control group,with 30 patients in each group.The patients in the treatment group were given embolization treatment with hepatic arterial infusion of TCM elemene emulsion,and those in the control group were given embolization treatment with hepatic arterial infusion of chemotherapy drugs.The two groups were compared in terms of TCM syndrome score,quality of life score,objective tumor response,toxic and side effects,and 1-year survival.Results：Compared with the control group,the treatment group had significantly better improvements in TCM syndrome and quality of life (P<0.01,P＜0.05),while there was no significant difference in objective tumor response between the two groups (P>0.05).The comparison of toxic and side effects showed that compared with the control group,the treatment group had significantly better hemoglobin count (HGB),platelet count,alanine aminotransferase,and alkaline phosphatase (all P＜0.01).As for the grade of toxic and side effects of the blood,digestive,and urinary systems,the treatment group had significantly better grades of all indices except HGB and total bilirubin than the control group (all P＜0.05).The treatment group had slightly better survival than the control group (P>0.05).Conclusion：In patients with primary liver cancer with stagnation of liver Qi and spleen deficiency and internal accumulation of stasis and toxin,embolization treatment with hepatic arterial infusion of TCM elemene emulsion can significantly improve their TCM symptoms and quality of life,with fewer toxic and side effects than infusion of chemotherapy drugs,and therefore,it holds promise for clinical research and application. |
| Key words: primary liver cancer interventional embolization elemene |
