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基于数据挖掘分析中药汤剂治疗肾病综合征的用药规律
唐梓椋,李 娇,徐锦龙
0
(大理大学药学院,云南 大理,671000;宁波市泌尿肾病医院,浙江 宁波,315100)
摘要:
目的:基于中医传承辅助平台分析中药汤剂治疗肾病综合征(NS)的用药规律。方法:检索中国知网(CNKI)、万方数据(WANFANG DATA)、维普中文科技期刊数据库(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Embase、The Cochrane Library等电子数据库,筛选2010年1月1日至2023年7月31日关于中药汤剂治疗NS的相关文献,并采用中医传承辅助平台TCMISS(V2.5)分析其药物功效、性味归经、关联规则等。结果:最终纳入78篇文献,方剂78首,涉及中药共140味。高频药物依次为黄芪、茯苓、白术、泽泻、丹参等。药物功效以补虚、利水渗湿、活血化瘀、清热、收涩为主。药物四气以温、平、寒性为主,五味以甘、苦、辛味为主,归经以脾、肾、肝经为主。关联规则分析得出94组药物组合,出现频次最多的组合为黄芪、茯苓,置信度最高的组合为山药、泽泻→茯苓,并演化得到6组核心药物组合及其新方药物组合。结论:中药汤剂治疗NS以利水渗湿、助阳化气、滋阴补血、健脾益肾药物为主,并根据病情辨证施治,可为临床诊疗提供一定的参考。
关键词:  肾病综合征  中药汤剂  中医传承辅助平台  用药规律
DOI:
Medication rule of traditional Chinese medicine decoctions in treatment of nephrotic syndrome: A study based on data mining
TANG Ziliang,LI Jiao,XU Jinlong
(School of Pharmacy,Dali University,Dali 671000,Yunnan,China;Ningbo Urinary and Renal Disease Hospital,Ningbo 315100,Zhejiang,China)
Abstract:
Objective: To investigate the medication rule of traditional Chinese medicine (TCM) decoctions in the treatment of nephrotic syndrome (NS) based on Traditional Chinese Medicine Inheritance Support System (TCMISS).Methods: Electronic databases such as CNKI,Wanfang Data,VIP,SinoMed,PubMed,Embase,and the Cochrane Library were searched for the articles on TCM decoction in the treatment of NS published from January 1,2010 to July 31,2023,and TCMISS V2.5 was used to analyze the function,nature,taste,meridian entry,and association rule of drugs.Results: A total of 78 articles were included,with 78 prescriptions involving 140 TCM drugs.Astragalus membranaceus had the highest frequency of use,followed by Poria cocos,Atractylodes macrocephala Koidz.,Alisma orientalis,and Salvia miltiorrhiza.The main functions of these drugs included tonifying deficiency,promoting diuresis and draining dampness,activating blood and resolving stasis,clearing heat,and inducing astringency.Most drugs had a warm,neutral or cold nature and a sweet,bitter or pungent taste,and they mainly entered the spleen,kidney,and liver meridians.The association rule analysis obtained 94 drug combinations,among which Astragalus membranaceus-Poria cocos had the highest frequency and Dioscorea opposite-Alisma orientalis-Poria cocos had the highest reliability,and finally 6 core drug combinations and their new prescriptions were obtained.Conclusion: In the treatment of NS,TCM decoctions mainly use the drugs for promoting diuresis and draining dampness,promoting Yang transforming Qi,nourishing Yin and nourishing blood,and strengthening the spleen and nourishing the kidney,and syndrome-differentiation treatment is given based on disease conditions,which can provide a certain reference for clinical diagnosis and treatment.
Key words:  nephrotic syndrome  traditional Chinese medicine decoction  Traditional Chinese Medicine Inheritance Support System  medication rule

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