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基于数据挖掘分析中医药改善晚期恶性肿瘤患者食欲减退的用药规律
李行远,郑蔚婵,李 辉
0
(湖南中医药大学,湖南 长沙,410208;湖南中医药大学附属常德医院,湖南 常德,415000)
摘要:
目的:基于数据挖掘分析中医药改善晚期恶性肿瘤患者食欲减退的用药规律。方法:检索自建库至2023年12月4日中国知网(CNKI)、万方数据(WANFANG DATA)、维普中文科技期刊数据库(VIP)、PubMed等有关中医药改善晚期恶性肿瘤患者食欲减退的文献,分析文献处方中的药物使用频次、功效、性味归经、药物配伍、聚类、复杂网络分析等。结果:共纳入处方61首,包含药物158味,药物使用频次排名前5位的依次为白术、茯苓、陈皮、党参、甘草;功效以补虚为主,其次为理气、消食、清热、利水、化痰;药性以温、平性为主;药味以甘、辛、苦味为主;归经以脾、肺、胃经为主;药物配伍显示白术、党参、茯苓、陈皮、甘草、砂仁之间的配伍最为频繁;聚类分析得到6组聚类组合;复杂网络分析显示四君子汤、六君子汤为核心处方。结论:晚期恶性肿瘤患者食欲减退的病因主要在于脾胃功能受损以及痰凝、食积、水停等,治疗上需兼顾健脾、益气、燥湿、化痰、消食、利水等,并注重补而不滞,疏而不损。
关键词:  恶性肿瘤  食欲减退  中医药疗法  数据挖掘
DOI:
Medication rule of traditional Chinese medicine in improving anorexia in patients with advanced malignant tumor: A study based on data mining
LI Xingyuan,ZHENG Weichan,LI Hui
(Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;Changde Hospital,Hunan University of Chinese Medicine,Changde 415000,Hunan,China)
Abstract:
Objective: To investigate the medication rule of traditional Chinese medicine (TCM) in improving anorexia in patients with advanced malignant tumor based on data mining.Methods: CNKI,Wanfang Data,VIP,and PubMed were searched for articles on TCM in improving anorexia in patients with advanced malignant tumor published up to December 4,2023,and the drugs in prescriptions were analyzed in terms of frequency of use,function,nature,taste,meridian entry,drug combination,cluster,and complex network analysis.Results: A total of 61 prescriptions were included,involving 158 TCM drugs.The top 5 drugs in terms of frequency of use were Atractylodes macrocephala Koidz.,Poria cocos,tangerine peel,Codonopsis pilosula,and Radix Glycyrrhizae.The drugs mainly had the function of tonifying deficiency,followed by regulating Qi,promoting digestion,clearing heat,promoting diuresis,and resolving phlegm.Most drugs had a warm or neutral nature and a sweet,pungent or bitter taste,and they mainly entered the spleen,lung,and stomach meridians.Drug combination showed the most frequent combination between Atractylodes macrocephala Koidz.,Codonopsis pilosula,Poria cocos,tangerine peel,Radix Glycyrrhizae,and Amomum villosum.The cluster analysis obtained 6 clusters,and the complex network analysis showed that Sijunzi Decoction and Liujunzi Decoction were core prescriptions.Conclusion: Impaired spleen and stomach functions,phlegm coagulation,dyspepsia,and water retention were the main etiologies of anorexia in patients with advanced malignant tumor,and the treatment of such patients should consider the therapies for strengthening the spleen,benefiting Qi,drying dampness,resolving phlegm,promoting digestion,and promoting diuresis,with emphasis on tonifying without causing stagnation and soothing without causing depletion of vital Qi.
Key words:  malignant tumor  anorexia  traditional Chinese medicine treatment  data mining

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